RANK/TNFRSF11A Products

Antibodies
RANK/TNFRSF11A Antibody
RANK/TNFRSF11A Antibody
AF692
Species: Mu
Applications: WB, IHC, AgAct
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Antibody Pairs
RANK/TNFRSF11A Antibody Pair
RANK/TNFRSF11A Antibody Pair
H00008792-AP41
Species: Hu
Applications: S-ELISA
ELISA Kits
RANK/TNFRSF11A ELISA Kit [Bio ...
RANK/TNFRSF11A ELISA Kit [Biotin]
KA2007
Species: Mu
RANK/TNFRSF11A ELISA Kit [Bio ...
RANK/TNFRSF11A ELISA Kit [Biotin]
KA1255
Species: Hu
Lysates
RANK/TNFRSF11A Overexpression ...
RANK/TNFRSF11A Overexpression Lysa...
NBL1-17145
Applications: WB
Proteins
RANK/TNFRSF11A Recombinant Pr ...
RANK/TNFRSF11A Recombinant Protein
NBP2-52304
Species: Hu
Applications: PAGE
RANK/TNFRSF11A Recombinant Pr ...
RANK/TNFRSF11A Recombinant Protein...
NBP1-85771PEP
Species: Hu
Applications: AC
RNAi
RANK/TNFRSF11A RNAi
RANK/TNFRSF11A RNAi
H00008792-R02
Species: Hu

Description

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Receptor activator of NF-kB (RANK) is a recently cloned member of the TNFR superfamily with no significant homology to other members of this family (1). RANK ligand (RANKL/TRANCE/ OPGL) (mAbs to RANKL is also available from Imgenex, Cat # IMG-133) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6 (3,4). Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathways (3). Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2 (4).

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Mouse
Product By Gene ID 8792
Alternate Names
  • CD265 antigen
  • OPTB7
  • tumor necrosis factor receptor superfamily member 11A
  • OFE
  • receptor activator of nuclear factor-kappa B
  • Receptor activator of NF-KB
  • loss of heterozygosity, 18, chromosomal region 1
  • Osteoclast differentiation factor receptor
  • TRANCER
  • tumor necrosis factor receptor superfamily, member 11a, activator of NFKB
  • PDB2
  • CD265
  • ODFROSTS
  • RANKLOH18CR1
  • FEO
  • tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Research Areas for RANK/TNFRSF11A

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Cell Cycle and Replication

Bioinformatics Tool for RANK/TNFRSF11A

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