Purine Nucleoside Phosphorylase/PNP Antibody (773511) [Alexa Fluor® 532]

• Applications: WB, IHC
• Clone: 773511
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

Purine Nucleoside Phosphorylase/PNP Antibody (773511) [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant human Purine Nucleoside Phosphorylase/PNP
  Met1-Ser289
  Accession # P00491
• Specificity: Detects human Purine Nucleoside Phosphorylase/PNP in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Purine Nucleoside Phosphorylase (PNP) catalyzes the phophorolysis of N-ribosidic bonds of purine nucleosides and deoxynucleosides. Physiological substrates of PNP include inosine, guanosine, and 2'-deoxyguanosine, but not adenosine (1). PNP is expressed in most tissues, with markedly greater expression in lymphoid tissues. Genetic deficiencies of PNP result in severely compromised T‑lymphocyte function and neurologic dysfunction (2, 3). PNP is used in assays for the measurement of inorganic phosphate (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.