PTP mu/PTPRM Antibody

Immunohistochemistry-Paraffin: PTP mu/PTPRM Antibody [NB110-39012] - Analysis of anti-PTPRM antibody with human retina at concentration 16 ug/ml.

Product Discontinued

PTP mu/PTPRM Antibody Summary

• Immunogen: Synthetic 16 amino acid peptide from internal region of human PTP mu/PTPRM.
• Localization: Internal domain of human.
• Specificity: Human PTPRM. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PTPRT (56%).
• Predicted Species: Mouse (94%), Rat (94%), Bat (94%), Equine (94%), Opossum (100%), Orangutan (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PTPRM
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 16 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Hamster (88%), Chicken (88%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PTP mu/PTPRM Antibody

• EC 3.1.3.48
• hR-PTPu
• MGC166994
• protein tyrosine phosphatase mu
• protein tyrosine phosphatase, receptor type, M
• protein tyrosine phosphatase, receptor type, mu polypeptide
• Protein-tyrosine phosphatase mu
• PTP mu
• PTPRL1
• PTPRL1R-PTP-MU
• PTPRM
• receptor-type tyrosine-protein phosphatase mu
• RPTPM
• R-PTP-mu
• RPTPU

Background

PTP mu, a R2A receptor protein tyrosine phosphatase, is composed of an extracellular segment containing a MAM domain, an immunoglobulin domain and four fibronectin type III repeats, a transmembrane segment, and two intracellular protein phosphatase domains. PTP mu has been shown to affect cell-cell aggregation, regulate cardiac myocyte Kv1.5 channel expression, and promote neurite outgrowth of retinal ganglion cells. The human PTP mu gene is localized on chromosome 18pter-q11, a region with frequent abnormalities implicated in human cancer. PTP mu may be important in responses to pathological conditions associated with the loss of cell-cell interactions in the heart.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPRM
• Entrez:
  • 5797(Human)
• Uniprot:
  • P28827()