PTP-MEG2/PTPN9 Antibody (291835) [Alexa Fluor® 700]

• Applications: WB
• Clone: 291835
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

PTP-MEG2/PTPN9 Antibody (291835) [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human PTP-MEG2
  Glu2-Gln593
  Accession # P43378
• Specificity: Detects human, mouse, and rat PTP-MEG2.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2), also known as PTPN9, contains an N-terminal domain homologous to the yeast retinaldehyde binding domain Sec14p and a C-terminal phosphatase domain. The Sec14p domain targets PTP-MEG2 to the membrane of secretory vesicles, where it promotes vesicle fusion. Elevated levels of membrane-bound PTP-MEG2 activity in erythroid progenitor cells are observed in polycythemia vera and may affect responsiveness to colony stimulating factors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.