PTP beta/zeta/PTPRZ Antibody - BSA Free

Western Blot: PTP beta/zeta/PTPRZ Antibody [NBP1-80916] - Analysis in human brain tissue.

Immunohistochemistry-Paraffin: PTP beta/zeta/PTPRZ Antibody [NBP1-80916] - Staining in human cerebral cortex and liver tissues . Corresponding PTPRZ1 RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: PTP beta/zeta/PTPRZ Antibody [NBP1-80916] - Staining of human cerebral cortex shows strong cytoplasmic positivity in a subset of neuronal cells.

Immunohistochemistry-Paraffin: PTP beta/zeta/PTPRZ Antibody [NBP1-80916] - Staining of human glioma shows moderate cytoplasmic positivity in tumor cells.

Immunohistochemistry-Paraffin: PTP beta/zeta/PTPRZ Antibody [NBP1-80916] - Staining of human liver shows no positivity as expected.

• Reactivity: Hu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

PTP beta/zeta/PTPRZ Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit PTP beta/zeta/PTPRZ Antibody - BSA Free (NBP1-80916) is a polyclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: LFRHLHTVSQILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDAMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIPKSSLIT
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PTPRZ1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
  • Western Blot 0.04-0.4 ug/ml
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  PTP beta/zeta/PTPRZ Recombinant Protein Antigen (NBP1-80916PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for PTP beta/zeta/PTPRZ Antibody - BSA Free

• 3F8 CSPG
• HPTPZ
• phosphacan
• protein tyrosine phosphatase, receptor-type, Z polypeptide 1
• PTP beta/zeta
• PTP18
• PTPRZ
• PTPRZ1
• PTPZ
• receptor-type, zeta polypeptide 1
• RPTPB
• RPTPbeta

Background

PTPRB is a member of the protein tyrosine phosphatase (PTP) family. The family comprises at least 37 proteins, characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. PTP1B is a transmembrane PTP. The PTPs have high substrate specificity for phosphotyrosyl proteins, at the primary sequence level sharing little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. PTP beta interacts with and regulates the tyrosine phosphorylation level of catenins, which are critical in physiological and pathological events such as cell migration, adhesion and transformation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPRZ1
• Entrez:
  • 5803(Human)
• Uniprot:
  • P23471()
  • P23471()
  • P23471()
  • P23471()