PTHLH/PTHrP Antibody (677939) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: IHC
• Clone: 677939
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

PTHLH/PTHrP Antibody (677939) [Alexa Fluor® 594] Summary

• Immunogen: E. coli-derived recombinant human PTHLH/PTHrP
  Ala37-Arg175
  Accession # P12272
• Specificity: Detects human PTHLH/PTHrP in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PTHLH/PTHrP Antibody (677939) [Alexa Fluor® 594]

• BDE2
• HHM
• MGC14611
• Osteostatin
• parathyroid hormone-like hormone
• Parathyroid hormone-like protein
• parathyroid hormone-related protein
• PLPosteostatin
• PTHLH
• PTHR
• PTH-related protein
• PTHRP
• PTH-rP
• PTHRPparathyroid hormone-like related protein

Background

The parathyroid hormone-like hormone (PTHLH), also known as PTHrP, has been recognized in patients suffering from tumors associated with the common neoplastic syndrome humoral hypercalcemia of malignancy (HHM). The 18 kDa protein is a 177 amino acid (aa) precursor that belongs to the parathyroid hormone family. It contains a 24 aa signal sequence followed by a 10 aa propeptide (aa 25-34). The mature chain runs from aa 37-177. Of note, residues 108-129 constitute a nuclear localization signal (NLS) providing evidence that the protein not only acts as a secreted factor, but in an intracrine manner as well. A second isoform is missing aa 176-177, and a 34 aa substitution for aa 176-177 produces a third isoform. There is a strong homology displayed between PTHLH and human parathyroid hormone (PTH) among the first 13 aa. Studies show that the similarity in this area is 67% at the aa and nucleotide levels. Indeed, eight of the first 13 aa of PTHLH and PTH are identical. Human PTHLH and mouse PTHLH share 86% aa sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.