PTHLH/PTHrP Antibody (677939) [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: IHC
• Clone: 677939
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 669

PTHLH/PTHrP Antibody (677939) [Janelia Fluor® 669] Summary

• Immunogen: E. coli-derived recombinant human PTHLH/PTHrP
  Ala37-Arg175
  Accession # P12272
• Specificity: Detects human PTHLH/PTHrP in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: PTHLH
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for PTHLH/PTHrP Antibody (677939) [Janelia Fluor® 669]

• BDE2
• HHM
• MGC14611
• Osteostatin
• parathyroid hormone-like hormone
• Parathyroid hormone-like protein
• parathyroid hormone-related protein
• PLPosteostatin
• PTHLH
• PTHR
• PTH-related protein
• PTHRP
• PTH-rP
• PTHRPparathyroid hormone-like related protein

Background

PTHLH is encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTHLH