Proteinase 3/Myeloblastin/PRTN3 Antibody (SR1444) - BSA Free

Western Blot: Proteinase 3/Myeloblastin/PRTN3 Antibody (SR1444) [NBP3-22274] - Western blot analysis using NBP3-22274 in HL60 cell lysate.

• Reactivity: Hu
• Applications: WB, IHC
• Clone: SR1444
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Proteinase 3/Myeloblastin/PRTN3 Antibody (SR1444) - BSA Free Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A synthesized peptide derived from human Proteinase 3/Myeloblastin/PRTN3 (Uniprot #: P24158)
• Specificity: Detects endogenous levels of total Proteinase 3/Myeloblastin/PRTN3
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: PRTN3
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50-1:200
  • Western Blot 1:500-1:2000
• Theoretical MW: 27 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, pH 7.4, 150mM NaCl, 50% glycerol.
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Proteinase 3/Myeloblastin/PRTN3 Antibody (SR1444) - BSA Free

• ACPA
• AGP7
• AGP7PR3
• azurophil granule protein 7
• C-ANCA
• EC 3.4.21
• EC 3.4.21.76
• Leukocyte proteinase 3
• MBN
• MBT
• Myeloblastin
• Neutrophil proteinase 4
• NP4
• NP-4
• P29C-ANCA antigen
• PR-3CANCA
• Proteinase 3
• PRTN3
• serine proteinase, neutrophil
• Wegener autoantigen
• Wegener granulomatosis autoantigen

Background

Myeloblastin (PR3) is a polymorphonuclear leukocyte serine protease which degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. PR3 plays a role in neutrophil response to inflammation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PRTN3