Human Trappin-2/Elafin DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Trappin-2/Elafin DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: PI3

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Trappin-2/Elafin DuoSet ELISA, 15 Plate

• cementoin
• Elafin
• Elastase-specific inhibitor
• ESI
• ESIWAP four-disulfide core domain protein 14
• Peptidase inhibitor 3
• peptidase inhibitor 3, skin-derived
• PI3
• PI-3
• pre-elafin
• protease inhibitor 3, skin-derived (SKALP)
• Protease inhibitor WAP3
• SKALP
• SKALPELAFIN
• Skin-derived antileukoproteinase
• Trappin2
• Trappin-2
• WAP four-disulfide core domain 14
• WAP3MGC13613
• WFDC14elafin

Background

Trappin-2 is a member of the trappin family that includes the SLPI (secretory leukocyte protease inhibitor) protein. Elafin or ESI (elastase-specific inhibitor) and SKALP (skin-derived anti-leukoproteinase) are alternative names for trappin-2 and reflect its protease targets. However, Elafin and SKALP sometimes correspond only to the processed form that contains the C-terminal WAP domain of the molecule.

Publications for Trappin-2/Elafin/Skalp (DY1747)(17)

Publications using DY1747

• Nasr, MA;Aldous, A;Daniels, J;Joy, C;Capozzi, E;Yang, M;Moriarty, P;Emmanuel-Baker, V;Malcolm, S;Green, SJ;Gomez-Lobo, V;Ghosh, M; Effect of progestin-based contraceptives on HIV-associated vaginal immune biomarkers and microbiome in adolescent girls PloS one 2024-07-15 [PMID: 39008499] (Human)
• S Cambier, M Metzemaeke, AC Carvalho, A Nooyens, C Jacobs, L Vanderbeke, B Malengier-, M Gouwy, E Heylen, P Meersseman, G Hermans, E Wauters, A Wilmer, C Consortium, D Schols, P Matthys, G Opdenakker, RE Marques, J Wauters, J Vandooren, P Proost Atypical response to bacterial co-infection and persistent neutrophilic broncho-alveolar inflammation distinguish critical COVID-19 from influenza JCI Insight, 2022-01-11;0(0):. 2022-01-11 [PMID: 34793331] (Human)
• K Ganguly, A Nordström, TA Thimraj, M Rahman, M Ramström, SI Sompa, EZ Lin, F O'Brien, J Koelmel, L Ernstgård, G Johanson, KJG Pollitt, L Palmberg, S Upadhyay Addressing the challenges of E-cigarette safety profiling by assessment of pulmonary toxicological response in bronchial and alveolar mucosa models Sci Rep, 2020-11-24;10(1):20460. 2020-11-24 [PMID: 33235237] (Human)
• J Wang, C Ortiz, L Fontenot, R Mukhopadhy, Y Xie, IKM Law, DQ Shih, SA Mattai, Z Li, HW Koon Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice Sci Rep, 2020-07-30;10(1):12785. 2020-07-30 [PMID: 32733043] (Human)
• J Wang, C Ortiz, L Fontenot, Y Xie, W Ho, SA Mattai, DQ Shih, HW Koon High circulating elafin levels are associated with Crohn's disease-associated intestinal strictures PLoS ONE, 2020-04-14;15(4):e0231796. 2020-04-14 [PMID: 32287314] (Human)
• M Xu, J Deng, K Xu, T Zhu, L Han, Y Yan, D Yao, H Deng, D Wang, Y Sun, C Chang, X Zhang, J Dai, L Yue, Q Zhang, X Cai, Y Zhu, H Duan, Y Liu, D Li, Y Zhu, TRDJ Radstake, DMW Balak, D Xu, T Guo, C Lu, X Yu In-depth serum proteomics reveals biomarkers of psoriasis severity and response to traditional Chinese medicine Theranostics, 2019-04-13;9(9):2475-2488. 2019-04-13 [PMID: 31131048] (Human)
• V Jespers, J Kyongo, S Joseph, L Hardy, P Cools, T Crucitti, M Mwaura, G Ndayisaba, S Delany-Mor, J Buyze, G Vanham, JHHM van de Wij A longitudinal analysis of the vaginal microbiota and vaginal immune mediators in women from sub-Saharan Africa Sci Rep, 2017-09-20;7(1):11974. 2017-09-20 [PMID: 28931859] (Human)
• Brissot E, Bossard C, Malard F, Braudeau C, Chevallier P, Guillaume T, Delaunay J, Josien R, Gregoire M, Gaugler B, Mohty M Involvement of the CX3CL1 (fractalkine)/CX3CR1 pathway in the pathogenesis of acute graft-versus-host disease. J Leukoc Biol, 2014-11-24;97(2):227-35. 2014-11-24 [PMID: 25420917] (Human)
• Frampton , John P, White , Joshua B, Simon , Arlyne B, Tsuei , Michael, Paczesny , Sophie, Takayama , Shuichi Aqueous two-phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA. Sci Rep, 2014-05-02;4(0):4878. 2014-05-02 [PMID: 24786974] (Human)
• Yin F, Battiwalla M, Ito S, Feng X, Chinian F, Melenhorst J, Koklanaris E, Sabatino M, Stroncek D, Samsel L, Klotz J, Hensel N, Robey P, Barrett A Bone marrow mesenchymal stromal cells to treat tissue damage in allogeneic stem cell transplant recipients: correlation of biological markers with clinical responses. Stem Cells, 2014-05-01;32(5):1278-88. 2014-05-01 [PMID: 24452962] (Human)
• Austin W. Boesch, Yifeng Zhao, Alison S. Landman, Marta Rodriguez Garcia, John V. Fahey, Charles R. Wira et al. A multiplexed assay to detect antimicrobial peptides in biological fluids and cell secretions Journal of Immunological Methods 2013-11-29 [PMID: 24035708] (Human)
• Kyongo J, Jespers V, Goovaerts O, Michiels J, Menten J, Fichorova R, Crucitti T, Vanham G, Arien K Searching for lower female genital tract soluble and cellular biomarkers: defining levels and predictors in a cohort of healthy Caucasian women. PLoS ONE, 2012-08-31;7(8):e43951. 2012-08-31 [PMID: 22952818] (Human)
• Lahey T, Ghosh M, Fahey JV, Shen Z, Mukura LR, Song Y, Cu-Uvin S, Mayer KH, Wright PF, Kappes JC, Ochsenbauer C, Wira CR Selective impact of HIV disease progression on the innate immune system in the human female reproductive tract. PLoS ONE, 2012-06-04;7(6):e38100. 2012-06-04 [PMID: 22675510] (Human)
• Drannik AG, Nag K, Yao XD, Henrick BM, Sallenave JM, Rosenthal KL Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:C. PLoS ONE, 2012-04-24;7(4):e35866. 2012-04-24 [PMID: 22545145] (Human)
• Drannik AG, Nag K, Yao XD, Henrick BM, Jain S, Ball TB, Plummer FA, Wachihi C, Kimani J, Rosenthal KL Anti-HIV-1 activity of elafin is more potent than its precursor's, trappin-2, in genital epithelial cells. J. Virol., 2012-02-15;86(8):4599-610. 2012-02-15 [PMID: 22345469] (Human)
• Pitteri SJ, JeBailey L, Faca VM, Thorpe JD, Silva MA, Ireton RC, Horton MB, Wang H, Pruitt LC, Zhang Q, Cheng KH, Urban N, Hanash SM, Dinulescu DM Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery. PLoS ONE, 2009-11-19;4(11):e7916. 2009-11-19 [PMID: 19936259] (Human)
• Ghosh M, Shen Z, Fahey JV, Cu-Uvin S, Mayer K, Wira CR Trappin-2/Elafin: a novel innate anti-human immunodeficiency virus-1 molecule of the human female reproductive tract. Immunology, 2009-07-18;0(0):. 2009-07-18 [PMID: 19824918] (Human)

FAQs for Trappin-2/Elafin/Skalp (DY1747). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: PI3