Protein S/PROS1 Antibody (8D5) - BSA Free

Product Discontinued

Protein S/PROS1 Antibody (8D5) - BSA Free Summary

• Immunogen: Protein S isolated from human plasma adsorbed onto aluminium hydroxide gel.
• Localization: Secreted.
• Specificity: Protein S
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: PROS1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
• Application Notes: A strong reaction is seen in sandwich ELISA in combination with a biotinlabeled antibody against protein S. Reactivity is Ca++ dependent and is optimal when using a tris-buffer containing 1 mM CaCl2. In Dot blotting SDS-treatment abolishes the reactivity
• Theoretical MW: 75 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 10mM Phosphate (pH 7.4) and 0.5M NaCl
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein A or G purified

Alternate Names for Protein S/PROS1 Antibody (8D5) - BSA Free

• EC 3.4.21
• PROS
• PROS1
• protein S (alpha)
• Protein S
• protein Sa
• PS21
• PS22
• PS23
• PS24
• PS25
• PSA
• vitamin K-dependent plasma protein S
• vitamin K-dependent protein S

Background

Protein S is a vitamin K-dependent, potent neutral anticoagulant plasma glycoprotein. Protein S has a molecular weight of approximately 70 kDa and consists of a single polypeptide chain. The concentration of protein S in human plasma is 25 ug/ml, with a half-life of approximately two days. About 40% of protein S in plasma is in a free form, whereas 60% is complexed with C4b-binding Protein (C4BP). Only the free protein S functions as a cofactor to antigen presenting cells (APC) in the APC-dependent degradation of Factor Va and Factor VIIIa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for Protein S/PROS1 Antibody (NBP1-05150). (Showing 1 - 1 of 1 FAQ).

1. Our customer interested in Protein S Antibody (8D5) #NBP1-05150 and would like to know whether its immunogen or epitope includes aa. 42-87 (Gla domain) of protein S precursor? Could you tell us if it could be disclosed?
   • The immunogen that was used to generate our Protein S antibody with catalogue number NBP1-05150 was the full length protein, which was isolated from human plasma. We do not epitope map our antibodies, and as such I am unable to tell you exactly where on the protein the antibody binds.

Bioinformatics

• Gene Symbol: PROS1