Protein Phosphatase 1 beta Antibody

Images

 
Western Blot: Protein Phosphatase 1 beta Antibody [NBP1-32618] - Various whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with PPP1CB antibody diluted at 1:1000. The ...read more
Immunocytochemistry/ Immunofluorescence: Protein Phosphatase 1 beta Antibody [NBP1-32618] - HeLa cells were fixed in 4% paraformaldehyde for 10 min. Green: PPP1CB protein stained by PPP1CB antibody iluted at 1:100. ...read more
Immunohistochemistry-Paraffin: Protein Phosphatase 1 beta Antibody [NBP1-32618] - Protein Phosphatase 1 beta Antibody detects Protein Phosphatase 1 beta protein at cytoplasm and nucleus by immunohistochemical analysis. ...read more
Western Blot: Protein Phosphatase 1 beta Antibody [NBP1-32618] - Sample (50 ug of whole cell lysate) A: Mouse brain 10% SDS PAGE; antibody diluted at 1:1000.
Immunohistochemistry-Paraffin: Protein Phosphatase 1 beta Antibody [NBP1-32618] - Mouse lung. Paraffin-embedded mouse lung. Dilution: 1:500.
Immunohistochemistry-Paraffin: Protein Phosphatase 1 beta Antibody [NBP1-32618] - Mouse hind brain dilution: 1:500.
Immunohistochemistry-Frozen: Protein Phosphatase 1 beta Antibody [NBP1-32618] - Frozen-sectioned adult mouse cerebellum. Green: PPP1CB stained by PPP1CB antibody diluted at 1:250. Red: NF-H, stained by NF-H antibody ...read more
Immunohistochemistry-Paraffin: Protein Phosphatase 1 beta Antibody [NBP1-32618] - Proetin Phosphatase 1 beta Antibody detects PPP1CB protein at cytoplasm and nucleus by immunohistochemical analysis. Sample: ...read more
Protein Phosphatase 1 beta Antibody [NBP1-32618] - Non-transfected (-) and transfected (+) 293T whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with Protein Phosphatase 1 beta ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Ca, Ch, Rb, RM, Xp, ZeSpecies Glossary
Applications WB, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Protein Phosphatase 1 beta Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human PPP1CB. The exact sequence is proprietary.
Localization
Cytoplasm
Predicted Species
Porcine (100%), Bovine (100%), Rabbit (100%), Zebrafish (99%), Rhesus Macaque (100%), Xenopus (100%), Chicken (100%), Canine (99%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PPP1CB
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 1:100-1:1000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Frozen 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
  • Western Blot 1:500-1:3000
Theoretical MW
37 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Xenopus laevis (100%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS, 20% Glycerol (pH7)
Preservative
0.025% Proclin 300
Purity
Immunogen affinity purified

Alternate Names for Protein Phosphatase 1 beta Antibody

  • EC 3.1.3.16
  • EC 3.1.3.53
  • MGC3672
  • PP1beta
  • PP-1Bprotein phosphatase 1, catalytic subunit, delta isoform
  • PPP1CD
  • protein phosphatase 1, catalytic subunit, beta isoform
  • protein phosphatase 1, catalytic subunit, beta isozyme
  • protein phosphatase 1-beta
  • protein phosphatase 1-delta
  • serine/threonine protein phosphatase PP1-beta catalytic subunit
  • serine/threonine-protein phosphatase PP1-beta catalytic subunit

Background

Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase that regulates an enormous variety of cellular functions through the interaction of its catalytic subunit (PP1c) with over fifty different established or putative regulatory subunits (1). The coordinated and reciprocal action of serine/threonine (Ser/Thr) protein kinases and phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for many biological processes. PP1 is ubiquitously distributed and regulates a broad range of cellular functions, including glycogen metabolism, cell-cycle progression and muscle relaxation. PP1 has evolved effective catalytic machinery but lacks substrate specificity. Substrate specificity is conferred upon PP1 through interactions with a large number of regulatory subunits (2). It has been shown that PP1 determines the efficacy of learning and memory by limiting acquisition and favoring memory decline. When PP1 is genetically inhibited during learning, short intervals between training episodes are sufficient for optimal performance (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on Protein Phosphatase 1 beta.

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c-Myc is a well-characterized transcription factor encoded by the c-Myc gene on human chromosome 8q24. This cellular proto-oncogene, also known as p62, is commonly activated in a variety of tumor cells and plays a crucial role in cellular proliferatio...  Read full blog post.

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Bioinformatics

Gene Symbol PPP1CB