Prostatic Acid Phosphatase/ACPP Antibody (911603R) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clone: 911603R
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

Prostatic Acid Phosphatase/ACPP Antibody (911603R) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human Prostatic Acid Phosphatase/ACPP in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Prostatic Acid Phosphatase/ACPP Antibody (911603R) [Alexa Fluor™ Plus 488]

• acid phosphatase, prostate
• ACP3
• ACP-3
• ACPP
• EC 3.1.3.2
• PAP
• Prostatic Acid Phosphatase
• prostatic acid phosphotase

Background

Prostatic Acid Phosphatase (ACPP) catalyzes the hydrolysis of a variety of phosphate monoesters, including phosphorylated proteins (1). The activity optimum of ACPP is in the pH range of 4 - 6, and the activity is inhibited by L(+)-tartrate. ACPP expression levels are highest in the prostate, with much lower expression in most other tissues. ACPP is a type I integral membrane protein of the plasma membrane and lysosomes, and a secreted form also exists (2). The concentration of ACPP is elevated in the circulation of prostate cancer patients, making the enzyme a marker for the progression of prostate cancer (3). Cellular ACPP has been shown to be a protein tyrosine phosphatase (4). Protein substrates include the epidermal growth factor receptor and HER-2 (5). Cellular ACPP is considered to function as a tumor suppressor (5).

1. Apostol, I. et al. (1985) Acta. Biochim. Pol. 32:187.
2. Schroeder, B. et al. (2007) Traffic 8:1676.
3. Gutman, E.B. et al. (1936) Am. J. Cancer 28:485.
4. Lin, M.F. and G.M. Clinton (1986) Biochem. J. 235:351.
5. Veeramani, S. et al. (2005) Endocr. Relat. Cancer 12:805.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.