PRL-3/PTP4A3 Antibody (334402) [PerCP]

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC, IP
• Clone: 334402
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: PerCP

PRL-3/PTP4A3 Antibody (334402) [PerCP] Summary

• Immunogen: E. coli-derived recombinant human PRL-3
  Ala2-Met173
  Accession # O75365
• Specificity: Detects endogenous human, mouse and rat PRL-3 in Western blots. In Western blots, this antibody does not cross‑react with recombinant human PRL-1 or PRL‑2.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: PTP4A3
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for PRL-3/PTP4A3 Antibody (334402) [PerCP]

• PRL3
• PRL-3
• PRL3EC 3.1.3.48
• PRL-3potentially prenylated protein tyrosine phosphatase
• PRL-Rprotein tyrosine phosphatase type IVA 3
• protein tyrosine phosphatase type IVA, member 3
• Protein-tyrosine phosphatase 4a3
• Protein-tyrosine phosphatase of regenerating liver 3
• PTP4A3

Background

PRL-3 is encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTP4A3