PRL-3/PTP4A3 Products

Description

PRL-3 is a newly identified metastasis related gene, which codes a 22 KDa nonclassical protein tyrosine phosphatase with a C-terminal prenylation motif. It is located at the cytoplasmic membrane when prenylated and in the nucleus when nonpreylated. PRL-3 has at least 75% amino-acid sequence similarity with PRL-1 and PRL-2, the other two members of the PRL family. Recently, Zeng and colleagues found that Chinese hamster ovary cells stably expressing PRL-3 exhibited enhanced motility, invasive activity, and induced metastatic tumor formation in nude mice. And in clinical study, PRL-3 is consistently over expressed in liver metastasis in colorectal cancer cells. These findings may provide PRL-3 is a new target for the early diagnosis of metastasis as well as the drug discovery.

Bioinformatics

Entrez	11156 Human
Product By Gene ID	11156
Alternate Names	PRL3 PRL-3 PRL3EC 3.1.3.48 PRL-3potentially prenylated protein tyrosine phosphatase PRL-Rprotein tyrosine phosphatase type IVA 3 protein tyrosine phosphatase type IVA, member 3 Protein-tyrosine phosphatase 4a3 Protein-tyrosine phosphatase of regenerating liver 3 PTP4A3

Research Areas for PRL-3/PTP4A3

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Protein Phosphatase