Prion protein Antibody (T16-R)

Images

 
Western Blot: Prion protein Antibody (T16-R) [NBP1-71667] - Prion protein in mouse brain extract (A), HEK293 cells producing recombinant human prion protein (B), and cells transfected with empty vector (C). 200 ug of ...read more
Western Blot: Prion protein Antibody (T16-R) [NBP1-71667] - Lanes A-C represent extracts (30 ug of total protein per lane) of PrP-KO CF-10 cells (A), mouse hippocampus (B) and HEK293 cells, transfected with mouse prion ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, ShSpecies Glossary
Applications WB, ELISA, IHC, IHC-Fr, IHC-P, IP
Clone
T16-R
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Prion protein Antibody (T16-R) Summary

Immunogen
Peptide derived from N-terminal peptide of human prion protein, just before the first octapeptide sequnce repeat.
Clonality
Monoclonal
Host
Rabbit
Gene
PRNP
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • ELISA 1:10000-1:20000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunoprecipitation 1:10-1:500

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Tris/HCl (pH 8.0) and 10 mg/ml BSA
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for Prion protein Antibody (T16-R)

  • CD230
  • CJD
  • fatal familial insomnia)
  • GSS
  • prion protein (p27-30)
  • prion protein PrP
  • prion protein
  • prion-related protein
  • PRIPMGC26679

Background

Prion diseases are transmissible neurodegenerative disorders which affect a range of mammalian species. In humans they can be inherited and sporadic as well as acquired by exposure to human prions. Prions appear to be composed principally of a conformational isomer of host-encoded prion protein and propagate by recruitment of cellular prion protein (1). The function of the cellular prion protein (PrP) is still poorly understood. It has been proposed that one unprecedented role for PrP is against Bax-mediated neuronal apoptosis. It has been shown that PrP potently inhibits Bax-induced cell death in human primary neurons (2). An impaired synaptic inhibition may be involved in the epileptiform activity seen in Creutzfeldt-Jakob and other neurodegenerative diseases and it is believed that loss of function of PrP may contribute to the early synaptic loss and neuronal degeneration seen in these diseases (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PRNP