Pregnancy Zone Protein Antibody (909813) [DyLight 755]

• Reactivity: Hu
• Applications: WB, ELISA
• Clone: 909813
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 755

Pregnancy Zone Protein Antibody (909813) [DyLight 755] Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Human embryonic kidney cell line HEK293-derived recombinant human Pregnancy Zone Protein/PZP
  Thr26-Val1482
  Accession # P20742
• Specificity: Detects human Pregnancy Zone Protein/PZP in direct ELISAs.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Mouse
• Gene: PZP
• Purity: Protein A or G purified from cell culture supernatant

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from cell culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Pregnancy Zone Protein Antibody (909813) [DyLight 755]

• C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
• CPAMD6
• Pregnancy Zone Protein
• pregnancy-zone protein
• PZP

Background

PZP is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PZP