Pregnancy Zone Protein Products

Description

PZP is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Bioinformatics

Entrez	5858 Human
Uniprot	NP_002855 Human
Product By Gene ID	5858
Alternate Names	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6 CPAMD6 pregnancy zone protein pregnancy-zone protein