WB: No signal obtained yet but low background observed in Raji, Daudi, MOLT-4 and human brain lysates at up to 2ug/ml. ChIP: This product has been successfully used in ChIP on Mouse: (Cell Transplant. 2011;20(8):1179-92). PMID: 21294954.
Read Publications using NB100-1088 in the following applications:
Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at firstname.lastname@example.org for more details.
Alternate Names for PRDM16/MEL1 Antibody
MDS1/EVI1-like gene 1
PR domain containing 16
PR domain zinc finger protein 16
PR domain-containing protein 16
Transcription factor MEL1
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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