PMP22 Antibody (Hu1) [HRP]

Product Discontinued

PMP22 Antibody (Hu1) [HRP] Summary

• Immunogen: Human PMP22 cDNA boosted with a 13-amino acid peptide of the 2nd extracellular domain (a.a. 120-133) conjugated to murine IgG. [Swiss-Prot# Q01453]
• Epitope: Detects amino acids 121-123 in the second extracellular domain of human PMP22.
• Localization: Membrane
• Marker: Schwann Cell Marker
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: PMP22
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: This PMP22 antibody is useful for Immunohistochemistry-Paraffin. Western Blot was reported in scientific literature.
• Readout System:
  • NovaLume Plus Chemiluminescent Reagent LUM-555

Reactivity Notes

Human and Rhesus monkey. Does not react with mouse, rat, or bovine nerve protein.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein G purified

Alternate Names for PMP22 Antibody (Hu1) [HRP]

• CMT1A
• CMT1E
• GAS3
• GAS-3DSS
• growth arrest-specific 3
• Growth arrest-specific protein 3
• HMSNIA
• HNPP
• MGC20769
• peripheral myelin protein 22
• PMP-22
• Sp110

Background

Peripheral Myelin Protein 22 (PMP22) is a 160 amino acid glycoprotein which is a member of the claudin family and is thought to play an important role in the structure of peripheral nerve myelin. Irregularities in its gene results in hereditary demyelinating neuropathies. PMP22 protein is present in the compact myelin of adult human peripheral nerve and its distribution mimics that of Myelin Protein zero (P0). Charcot-Marie-Tooth Disease (CMT) Type 1A, the most common form of CMT, is caused by a genetic duplication that results in the overproduction of PMP22, which causes myelin sheathing to deteriorate and results in severe muscle atrophy and weakness in the body's extremities.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PMP22