PMP22 Antibody (Hu1) [FITC]

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Product Details

Summary
Reactivity Hu, Pm, Bv(-), Mu(-), Rt(-)Species Glossary
Applications IHC, IHC-P
Clone
Hu1
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

PMP22 Antibody (Hu1) [FITC] Summary

Immunogen
Human PMP22 cDNA boosted with a 13-amino acid peptide of the 2nd extracellular domain (a.a. 120-133) conjugated to murine IgG. [Swiss-Prot# Q01453]
Epitope
Detects amino acids 121-123 in the second extracellular domain of human PMP22.
Localization
Membrane
Marker
Schwann Cell Marker
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
PMP22
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This PMP22 antibody is useful for Immunohistochemistry-Paraffin. Western Blot was reported in scientific literature.

Reactivity Notes

Human and Rhesus monkey. Does not react with mouse, rat, or bovine nerve protein.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for PMP22 Antibody (Hu1) [FITC]

  • CMT1A
  • CMT1E
  • GAS3
  • GAS-3DSS
  • growth arrest-specific 3
  • Growth arrest-specific protein 3
  • HMSNIA
  • HNPP
  • MGC20769
  • peripheral myelin protein 22
  • PMP-22
  • Sp110

Background

PMP22 (peripheral myelin protein-22) is an integral membrane glycoprotein of internodal myelin and comprises an estimated 2-5 % of total myelin protein contents of peripheral nervous system. Its functional importance is emphasized by the fact that PMP22 gene mutations are the most common causes for inherited peripheral nerve disorders, also known as CMT (Charcot-Marie-Tooth diseases). Mutations of PMP22 are responsible for more than half of all the patients with inherited peripheral neuropathies, including CMT1A/CMT- type-1A with trisomy of PMP22, hereditary neuropathy with liability to pressure palsies (HNPP) with heterozygous deletion of PMP22, and CMT1E with point mutations of PMP22. These PMP22 associated disorders disrupt the organization of myelin, and subsequently axonal integrity which is untimately responsible for disabilities in patients. While overexpression and point-mutations of the PMP22 gene produces gain-of-function phenotypes, PMP22 deletion results in a loss-of-function phenotype that reveals the normal physiological functions of the PMP22 protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PMP22 Antibody (NB110-59086F) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NB110-59086B
DyLight 405 Labeled NB110-59086V
DyLight 488 Labeled NB110-59086G
DyLight 550 Labeled NB110-59086R
DyLight 650 Labeled NB110-59086C
HRP Labeled NB110-59086H

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Bioinformatics Tool for PMP22 Antibody (NB110-59086F)

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Blogs on PMP22.

PMP22 Antibodies Assist in PNS Myelin Repair Research
Novus Biologicals recently added a new  PMP22 antibody, conjugated to Biotin, to our antibody database. PMP22 (Peripheral Myelin Protein 22) is important to the structure of the myelin sheath in peripheral nerves, and is encoded by the PMP22 gene.Th...  Read full blog post.

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Bioinformatics

Gene Symbol PMP22