PMP22 Antibody (Hu1) [DyLight 650]

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Product Details

Summary
Reactivity Hu, Pm, Bv(-), Mu(-), Rt(-)Species Glossary
Applications WB, IHC, IHC-P
Clone
Hu1
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 650

PMP22 Antibody (Hu1) [DyLight 650] Summary

Immunogen
Human PMP22 cDNA boosted with a 13-amino acid peptide of the 2nd extracellular domain (a.a. 120-133) conjugated to murine IgG. [Swiss-Prot# Q01453]
Epitope
Detects amino acids 121-123 in the second extracellular domain of human PMP22.
Localization
Membrane
Marker
Schwann Cell Marker
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
PMP22
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This PMP22 antibody is useful for Immunohistochemistry-Paraffin. Western Blot was reported in scientific literature.

Reactivity Notes

Human and Rhesus monkey. Does not react with mouse, rat, or bovine nerve protein.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for PMP22 Antibody (Hu1) [DyLight 650]

  • CMT1A
  • CMT1E
  • GAS3
  • GAS-3DSS
  • growth arrest-specific 3
  • Growth arrest-specific protein 3
  • HMSNIA
  • HNPP
  • MGC20769
  • peripheral myelin protein 22
  • PMP-22
  • Sp110

Background

Peripheral Myelin Protein 22 (PMP22) is a 160 amino acid glycoprotein which is a member of the claudin family and is thought to play an important role in the structure of peripheral nerve myelin. Irregularities in its gene results in hereditary demyelinating neuropathies. PMP22 protein is present in the compact myelin of adult human peripheral nerve and its distribution mimics that of Myelin Protein zero (P0). Charcot-Marie-Tooth Disease (CMT) Type 1A, the most common form of CMT, is caused by a genetic duplication that results in the overproduction of PMP22, which causes myelin sheathing to deteriorate and results in severe muscle atrophy and weakness in the body's extremities.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PMP22 Antibody (NB110-59086C) (0)

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for PMP22 Antibody (NB110-59086C) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin Labeled NB110-59086B
DyLight 405 Labeled NB110-59086V
DyLight 488 Labeled NB110-59086G
DyLight 550 Labeled NB110-59086R
FITC Labeled NB110-59086F
HRP Labeled NB110-59086H

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Bioinformatics Tool for PMP22 Antibody (NB110-59086C)

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Research Areas for PMP22 Antibody (NB110-59086C)

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Blogs on PMP22.

PMP22 Antibodies Assist in PNS Myelin Repair Research
Novus Biologicals recently added a new  PMP22 antibody, conjugated to Biotin, to our antibody database. PMP22 (Peripheral Myelin Protein 22) is important to the structure of the myelin sheath in peripheral nerves, and is encoded by the PMP22 gene.Th...  Read full blog post.

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Bioinformatics

Gene Symbol PMP22