PMP22 Antibody (Hu1) [Alexa Fluor® 594]

Product Discontinued

PMP22 Antibody (Hu1) [Alexa Fluor® 594] Summary

• Immunogen: Human PMP22 cDNA boosted with a 13-amino acid peptide of the 2nd extracellular domain (a.a. 120-133) conjugated to murine IgG. [Swiss-Prot# Q01453]
• Epitope: Detects amino acids 121-123 in the second extracellular domain of human PMP22.
• Localization: Membrane
• Marker: Schwann Cell Marker
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: PMP22
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Human and Rhesus monkey. Does not react with mouse, rat, or bovine nerve protein.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for PMP22 Antibody (Hu1) [Alexa Fluor® 594]

• CMT1A
• CMT1E
• GAS3
• GAS-3DSS
• growth arrest-specific 3
• Growth arrest-specific protein 3
• HMSNIA
• HNPP
• MGC20769
• peripheral myelin protein 22
• PMP-22
• Sp110

Background

Peripheral Myelin Protein 22 (PMP22) is a 160 amino acid glycoprotein which is a member of the claudin family and is thought to play an important role in the structure of peripheral nerve myelin. Irregularities in its gene results in hereditary demyelinating neuropathies. PMP22 protein is present in the compact myelin of adult human peripheral nerve and its distribution mimics that of Myelin Protein zero (P0).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PMP22