PMP22 Antibody (Hu1)


Immunohistochemistry: PMP22 Antibody (Hu1) [NB110-59086] - Staining of PMP22 (brown) in dorsal root ganglion and spinal roots in 20 week fetal spinal cord preparation from rhesus monkey.

Product Details

Reactivity Hu, Pm, Bv(-), Mu(-), Rt(-)Species Glossary
Applications WB, IHC, IHC-P
0.9 mg/ml

PMP22 Antibody (Hu1) Summary

Human PMP22 cDNA boosted with a 13-amino acid peptide of the 2nd extracellular domain (a.a. 120-133) conjugated to murine IgG. [Swiss-Prot# Q01453]
Detects amino acids 121-123 in the second extracellular domain of human PMP22.
Schwann Cell Marker
IgG1 Kappa
Protein G purified
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Packaging, Storage & Formulations

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Tris-Glycine and 0.15M NaCl
0.05% Sodium Azide
0.9 mg/ml
Protein G purified


  • Western Blot
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
This PMP22 antibody is useful for Immunohistochemistry-Paraffin. Western Blot was reported in scientific literature.
Read Publication using
NB110-59086 in the following applications:

  • IHC
    1 publication
  • WB
    1 publication

Reactivity Notes

Human and Rhesus monkey. Does not react with mouse, rat, or bovine nerve protein.

Alternate Names for PMP22 Antibody (Hu1)

  • CMT1A
  • CMT1E
  • GAS3
  • GAS-3DSS
  • growth arrest-specific 3
  • Growth arrest-specific protein 3
  • HNPP
  • MGC20769
  • peripheral myelin protein 22
  • PMP-22
  • Sp110


PMP22 (peripheral myelin protein-22) is an integral membrane glycoprotein of internodal myelin and comprises an estimated 2-5 % of total myelin protein contents of peripheral nervous system. Its functional importance is emphasized by the fact that PMP22 gene mutations are the most common causes for inherited peripheral nerve disorders, also known as CMT (Charcot-Marie-Tooth diseases). Mutations of PMP22 are responsible for more than half of all the patients with inherited peripheral neuropathies, including CMT1A/CMT- type-1A with trisomy of PMP22, hereditary neuropathy with liability to pressure palsies (HNPP) with heterozygous deletion of PMP22, and CMT1E with point mutations of PMP22. These PMP22 associated disorders disrupt the organization of myelin, and subsequently axonal integrity which is untimately responsible for disabilities in patients. While overexpression and point-mutations of the PMP22 gene produces gain-of-function phenotypes, PMP22 deletion results in a loss-of-function phenotype that reveals the normal physiological functions of the PMP22 protein.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PMP22 Antibody (NB110-59086)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC, WB.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for PMP22 Antibody (NB110-59086). (Showing 1 - 1 of 1 FAQ).

  1. Does this antibody recognize ONLY human PMP22, or does it also recognize mouse PMP22? I am looking for something that will detect ONLY human cells, transplanted into a mouse brain.
    • We have confirmed that this antibody does not detect the mouse protein so this would be a good candidate for you. I would recommend using a directly conjugated primary antibody, as this will eliminate some of the background you may see by using an anti mouse secondary in mouse brain.

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB110-59086AF405
Alexa Fluor 488 Labeled NB110-59086AF488
Alexa Fluor 647 Labeled NB110-59086AF647
Alexa Fluor 700 Labeled NB110-59086AF700
Biotin Labeled NB110-59086B
DyLight 405 Labeled NB110-59086V
DyLight 488 Labeled NB110-59086G
DyLight 550 Labeled NB110-59086R
DyLight 650 Labeled NB110-59086C
FITC Labeled NB110-59086F
HRP Labeled NB110-59086H

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Blogs on PMP22.

PMP22 Antibodies Assist in PNS Myelin Repair Research
Novus Biologicals recently added a new¬† PMP22 antibody, conjugated to Biotin, to our antibody database. PMP22 (Peripheral Myelin Protein 22) is important to the structure of the myelin sheath in peripheral nerves, and is encoded by the PMP22 gene.Th...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol PMP22

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