Phospholipid Scramblase 1/PLSCR1 Antibody

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Western Blot: Phospholipid Scramblase 1/PLSCR1 Antibody [NBP1-32588] - Scramblase 1 Antibody [NBP1-32588] - whole cell lysate)A:HeLa S3 10% SDS PAGE, antibody diluted at 1:1000.
Immunocytochemistry/ Immunofluorescence: Phospholipid Scramblase 1/PLSCR1 Antibody [NBP1-32588] - A431 cells were fixed in ice-cold MeOH for 5 min. Green: PLSCR1 protein stained by Scramblase1 antibody [N1C3] diluted at ...read more
Immunohistochemistry-Paraffin: Phospholipid Scramblase 1/PLSCR1 Antibody [NBP1-32588] - Paraffin-embedded MDAMB468 xenograft, using antibody at 1:500 dilution.

Product Details

Summary
Reactivity Hu, MkSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.52 mg/ml

Order Details

Phospholipid Scramblase 1/PLSCR1 Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human Scramblase1. The exact sequence is proprietary.
Localization
Membrane, Single-pass type II membrane protein
Predicted Species
Monkey (96%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PLSCR1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunocytochemistry/Immunofluorescence 1:100-1:1000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
Theoretical MW
35 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Rhesus Monkey (96%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.52 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Phospholipid Scramblase 1/PLSCR1 Antibody

  • Erythrocyte phospholipid scramblase
  • MMTRA1B
  • MMTRA1BCa(2+)-dependent phospholipid scramblase 1
  • Phospholipid Scramblase 1
  • PL scramblase 1
  • PLSCR1

Background

Phospholipid scramblase 1 (PLSCR1) is a member of the PLSCR protein family. These proteins are ATP-independent lipid translocators localized to the plasma membrane and is involved in a calcium dependent, nonspecific and rapid redistribution (scrambling) of phospholipids when a perturbation of plasma membrane asymmetry is needed for the cell (e.g. following cell activation, injury, or apoptosis). The expression of PLSCR1 is found in a variety of tissue and can be stress-induced. Upon stimulation (e.g. interferon stimulation), a portion of newly synthesized PLSCR1 is imported into the nucleus (instead of inserted into the plasma membrane) and interacts with DNA, consistent with a role in gene regulation. PLSCR1 may be closely associated with the pathophysiology underlying infection and inflammation, which manifest marked changes in energy consumption and lipid metabolism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PLSCR1
Entrez