Immunocytochemistry/ Immunofluorescence: Phospholipid Scramblase 1/PLSCR1 Antibody [NBP1-32588] - A431 cells were fixed in ice-cold MeOH for 5 min. Green: PLSCR1 protein stained by Scramblase1 antibody [N1C3] diluted at ...read more
Immunohistochemistry-Paraffin: Phospholipid Scramblase 1/PLSCR1 Antibody [NBP1-32588] - Paraffin-embedded MDAMB468 xenograft, using antibody at 1:500 dilution.
35 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Immunogen affinity purified
Alternate Names for Phospholipid Scramblase 1/PLSCR1 Antibody
Erythrocyte phospholipid scramblase
MMTRA1BCa(2+)-dependent phospholipid scramblase 1
Phospholipid Scramblase 1
PL scramblase 1
Phospholipid scramblase 1 (PLSCR1) is a member of the PLSCR protein family. These proteins are ATP-independent lipid translocators localized to the plasma membrane and is involved in a calcium dependent, nonspecific and rapid redistribution (scrambling) of phospholipids when a perturbation of plasma membrane asymmetry is needed for the cell (e.g. following cell activation, injury, or apoptosis). The expression of PLSCR1 is found in a variety of tissue and can be stress-induced. Upon stimulation (e.g. interferon stimulation), a portion of newly synthesized PLSCR1 is imported into the nucleus (instead of inserted into the plasma membrane) and interacts with DNA, consistent with a role in gene regulation. PLSCR1 may be closely associated with the pathophysiology underlying infection and inflammation, which manifest marked changes in energy consumption and lipid metabolism.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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