Phospho-Akt (S473) Pan Specific DuoSet IC ELISA, 2 Plate

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

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Catalog# & Conjugate Size Price
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Catalog# & Formulation Size Price

Phospho-Akt (S473) Pan Specific DuoSet IC ELISA, 2 Plate Summary

Modification
p Ser473
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DYC887B-2.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Phospho-Akt (S473) Pan Specific DuoSet IC ELISA, 2 Plate

  • RAC-ALPHA
  • AKT serine/threonine kinase 1
  • Akt
  • PKB
  • PKB-ALPHA
  • PRKBA
  • RAC

Background

Akt1, Akt2, and Akt3 make up a family of serine/threonine kinases, often activated downstream of growth factor receptors and PI 3-Kinase. Each Akt family member contains an N-terminal pleckstrin homology (PH) domain, a central kinase domain, and a C-terminal regulatory domain. They have putative roles in cell proliferation and survival, and Akt perturbations are thought to play an important role in tumorigenesis.

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Publications for AKT (DYC887B-2)(10)

We have publications tested in 3 confirmed species: Human, Mouse, Hamster.


Filter By Application
All Applications
Filter By Species
Human
(6)
Mouse
(3)
Hamster
(1)
All Species
Showing Publications 1 - 10 of 10.
Publications using DYC887B-2 Applications Species
A Tutusaus, E de Gregori, B Cucarull, H Cristóbal, C Aresté, I Graupera, M Coll, A Colell, G Gausdal, JB Lorens, P García de, A Morales, M Marí A FUNCTIONAL ROLE OF GAS6/TAM IN NON-ALCOHOLIC STEATOHEPATITIS PROGRESSION IMPLICATES AXL AS THERAPEUTIC TARGET Cell Mol Gastroenterol Hepatol, 2019;0(0):. 2019 [PMID: 31689560] (Human) Human
G Zhou, X Han, Z Wu, Q Shi, X Bao Rosiglitazone accelerates wound healing by improving endothelial precursor cell function and angiogenesis in db/db mice PeerJ, 2019;7(0):e7815. 2019 [PMID: 31637120] (Mouse) Mouse
B Marcus-Sam, CC Krieger, A Boutin, G Kahaly, S Neumann, MC Gershengor Evidence that Graves' Ophthalmopathy Immunoglobulins Do Not Directly Activate IGF-1 Receptors Thyroid, 2018;0(0):. 2018 [PMID: 29631510] (Human) Human
Neurotensin stimulates sortilin and mTOR in human microglia inhibitable by methoxyluteolin, a potential therapeutic target for autism Proc Natl Acad Sci USA, 2016;0(0):. 2016 [PMID: 27663735] (Human) Human
Ray, Rupa, de Ridder, Gustaaf, Eu, Jerry P, Paton, Adrienne, Paton, James C, Pizzo, Salvator The Escherichia coli subtilase cytotoxin A subunit specifically cleaves cell-surface GRP78 protein and abolishes COOH-terminal-dependent signaling. J Biol Chem, 2012;287(39):32755-69. 2012 [PMID: 22851173] (Human) Human
Zhang Y, Gonzalez RM, Zangar RC Protein secretion in human mammary epithelial cells following HER1 receptor activation: influence of HER2 and HER3 expression. BMC Cancer, 2011;11(0):69. 2011 [PMID: 21320340] (Human) Human
Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse. J. Cell. Biochem., 2010;109(6):1185-91. 2010 [PMID: 20186881] (Mouse) Mouse
Hsieh CH, Nickel EA, Chen J, Schwacha MG, Choudhry MA, Bland KI, Chaudry IH Mechanism of the salutary effects of estrogen on kupffer cell phagocytic capacity following trauma-hemorrhage: pivotal role of Akt activation. J. Immunol., 2009;182(7):4406-14. 2009 [PMID: 19299741] (Mouse) Mouse
Struyf S, Noppen S, Loos T, Mortier A, Gouwy M, Verbeke H, Huskens D, Luangsay S, Parmentier M, Geboes K, Schols D, Van Damme J, Proost P Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4. J. Immunol., 2009;182(1):666-74. 2009 [PMID: 19109200] (Human) Human
Loos T, Mortier A, Gouwy M, Ronsse I, Put W, Lenaerts JP, Van Damme J, Proost P Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. Blood, 2008;112(7):2648-56. 2008 [PMID: 18645041] (Hamster) Hamster

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for AKT (DYC887B-2). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

Biotin DYC887B-2
Biotin DYC887B-2
Biotin DYC887B-2

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Array DYC887B-2

Diseases for AKT (DYC887B-2)

Discover more about diseases related to AKT (DYC887B-2).
 

Pathways for AKT (DYC887B-2)

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PTMs for AKT (DYC887B-2)

Learn more about PTMs related to AKT (DYC887B-2).

Blogs on AKT. Showing 1-10 of 29 blog posts - Show all blog posts.

Insulin signaling in adipocytes: Carbohydrate-signaling transcription factor ChREBP is the link between lipolytic enzyme Hormone-Sensitive Lipase and lipogenic enzyme ELOVL6
By Jamshed Arslan, Pharm. D., PhD. Insulin resistance in adipocytes is a major feature of metabolic syndrome   . Disrupted adipose tissue metabolism can lead to accumulation of lipid intermediates in insul...  Read full blog post.

mTOR Signaling and the Tumor Microenvironment
By Yoskaly Lazo-Fernandez, PhD The mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that, as a member of two distinct intracellular protein complexes, mTORC1 and mTORC2, regulates protein...  Read full blog post.

Novel Insights into Hypoxia Induced AKT Signaling
Hypoxia is a common feature of most tumors and is a product of rapid cell growth and poor vascularization1. When oxygen availability is low in the tumor environment, the hypoxia inducing transcription factors (HIFs) regulate a variety of signaling...  Read full blog post.

Pathway Highlight: Three key factors that contribute to cellular heterogeneity in apoptosis
Have you ever wondered why cells in the same population respond differently to an apoptotic stimulus? Apoptosis, a form of programmed cell death, is vital for the removal of unwanted or damaged cells. As with most cellular processes, too much or to...  Read full blog post.

The role of c-Fos in the regulation of the JC virus gene transcription
c-Fos is a member of the AP-1 transcription factor family under the Fos protein family umbrella, alongside Fra-1, Fra-2 and Fos-B.  Also in the AP-1 transcription family are the Jun proteins, c-Jun, Jun-B and Jun-D.  Each member of the AP-1 transcri...  Read full blog post.

Pathway Highlight: Which caspase substrates contribute to the morphological features associated with apoptosis?
Apoptosis, or programmed cell death, is controlled by a caspase signal cascade that activates downstream signals to induce the morphological changes used to differentiate apoptosis from other forms of cell death.  Novus Biologicals offers a variet...  Read full blog post.

The use of apoptosis antibodies and controls in cell death research
Apoptosis is a method of programmed cell death that is notably characterized by a morphological change in cellular nuclei and membrane appearance.  Not to be confused with necrosis, apoptosis is a pathway that is induced by a variety of factors tha...  Read full blog post.

The role of Parkin and autophagy in retinal pigment epithelial cell (RPE) degradation
The root of Parkinson’s disease (PD) points to a poorly regulated electron transport chain leading to mitochondrial damage, where many proteins need to work cohesively to ensure proper function.  The two key players of this pathway are PINK1,...  Read full blog post.

The effects of curcumin on IKB Alpha and the NFkB signaling pathway
The IKK complex, or inhibitor of NFkB kinase, is composed of IKK alpha and IKK beta.  These kinases are at the core of the NFkB signaling cascade.  The NFkB family is made up of transcription factors that are kept inactive in the cytoplasm through...  Read full blog post.

AMPK Alpha 1 and lipid metabolism of adipocytes
AMP-activated protein kinase (AMPK) is best known as a sensor of oxidative stress.  AMPK is activated by increased intracellular AMP levels, which are a result of alterations in cellular metabolism from causes such as hypoxia, changes in ATP, sene...  Read full blog post.

Showing 1-10 of 29 blog posts - Show all blog posts.
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