PGD2 Synthase/PTGDS Antibody [Alexa Fluor® 594]

• Reactivity: Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 594

PGD2 Synthase/PTGDS Antibody [Alexa Fluor® 594] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant rat PGD2 Synthase/PTGDS
  Gln25-Glu189
  Accession # P22057
• Specificity: Detects rat PGD2 Synthase/PTGDS in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PGD2 Synthase/PTGDS Antibody [Alexa Fluor® 594]

• Beta-trace protein
• Cerebrin-28
• EC 5.3.99.2
• Glutathione-independent PGD synthase
• glutathione-independent PGD synthetase
• lipocalin-type prostaglandin D synthase
• Lipocalin-type prostaglandin-D synthase
• L-PGDS
• PDS
• PGD2 Synthase
• PGD2
• PGDS2
• PGDSLPGDS
• PH2DISO
• prostaglandin D synthase
• prostaglandin D2 synthase (21kD, brain)
• prostaglandin D2 synthase 21kDa (brain)
• Prostaglandin-D2 synthase
• prostaglandin-H2 D-isomerase
• PTGDS

Background

PGD2 Synthase (prostaglandin D2 synthase; also PG-H2 D-isomerase) is a 26 kDa, monomeric member of the lipocalin family of proteins. It is expressed by neurons and astrocytes, retinal pigment epithelium and Sertoli cells. It catalyzes the conversion of PGH₂ to PGD₂, thereby influencing sleep and body temperature. It also transports retinoic acid. The rat PGD2 precursor is 189 amino acids (aa) in length. It contains a signal sequence (aa 1‑24) plus a lipocalin region that serves both as a catalytic site and hydrophobic molecule transporter (aa 40‑187). PGD2 is both intracellular and secreted. When secreted, PGD2 is called beta -Trace. One splice variant is likely intracellular and shows an 11 aa substitution for the first 52 amino acids. Over aa 25‑189, rat PGD2 shares 72% and 88% aa identity with human and mouse PGD2, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.