PGD2 Synthase/PTGDS Antibody (997303) [Alexa Fluor® 532]

• Reactivity: Hu, Rt
• Applications: WB, IHC
• Clone: 997303
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

PGD2 Synthase/PTGDS Antibody (997303) [Alexa Fluor® 532] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human PGD2 Synthase/PTGDS
  Met1-Gln190
  Accession # P41222
• Specificity: Detects human and rat PGD2 Synthase/PTGDS in direct ELISA and Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PGD2 Synthase/PTGDS Antibody (997303) [Alexa Fluor® 532]

• Beta-trace protein
• Cerebrin-28
• EC 5.3.99.2
• Glutathione-independent PGD synthase
• glutathione-independent PGD synthetase
• lipocalin-type prostaglandin D synthase
• Lipocalin-type prostaglandin-D synthase
• L-PGDS
• PDS
• PGD2 Synthase
• PGD2
• PGDS2
• PGDSLPGDS
• PH2DISO
• prostaglandin D synthase
• prostaglandin D2 synthase (21kD, brain)
• prostaglandin D2 synthase 21kDa (brain)
• Prostaglandin-D2 synthase
• prostaglandin-H2 D-isomerase
• PTGDS

Background

Prostaglandin-H2 D-isomerase or PGD2 synthase (PTGDS) is an enzyme that catalyzes the conversion of Prostaglandin H2 (PGH2) to Prostaglandin D2 (PGD2), a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Prostaglandin D2 synthase is used clinically as a diagnostic marker for Cerebrospinal fluid rhinorrhea, important in the assessment of head trauma severity. It has been also proposed that the urinary and serum levels pf PTGDS may be also a marker of renal damage in diabetes mellitus and hypertension.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.