Peripherin 2/PRPH2 Antibody [mFluor Violet 450 SE]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: mFluor Violet 450 SE

Peripherin 2/PRPH2 Antibody [mFluor Violet 450 SE] Summary

• Immunogen: peripherin 2(retinal degeneration, slow). (Uniprot# P23942)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PRPH2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Peripherin 2/PRPH2 Antibody [mFluor Violet 450 SE]

• AOFMD
• AVMD
• CACD2
• CACD2peripherin 2, homolog of mouse
• DS
• peripherin 2 (retinal degeneration, slow)
• Peripherin 2
• peripherin-2
• PRPH2
• PRPHperipherin, photoreceptor type
• rd2
• RDS
• Retinal degeneration slow protein
• retinal degeneration, slow
• retinal peripherin
• RP7
• Tetraspanin-22
• TSPAN22
• tspan-22
• TSPAN22retinal degeneration, slow (retinitis pigmentosa 7)

Background

The protein encoded by the PRPH2 gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. This protein is essential for disk morphogenesis. Defects in this gene are associated with both central and peripheral retinal degenerations. Some of the various phenotypically different disorders are autosomal dominant retinitis pigmentosa, progressive macular degeneration, macular dystrophy and retinitis pigmentosa digenic. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PRPH2