PDGFRL Antibody (1008804) [Alexa Fluor™ Plus 405]

• Reactivity: Hu
• Clone: 1008804
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 405

PDGFRL Antibody (1008804) [Alexa Fluor™ Plus 405] Summary

• Specificity: Detects human PDGFRL in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PDGFRL Antibody (1008804) [Alexa Fluor™ Plus 405]

• PDGFRL
• PDGFR-Like Protein
• PDGRL
• platelet-derived growth factor receptor-like protein
• platelet-derived growth factor receptor-like
• platelet-derived growth factor-beta-like tumor suppressor
• PRLTS
• PRLTSPDGF receptor beta-like tumor suppressor

Background

Platelet-derived growth factor receptor-like protein is a 67 kDa glycoprotein protein consisting of two Ig-like C2-type domains. By sequence similarity, human PDGFRL is 90% similar to the mouse version and 91% similar to that of the rat. It is a secreted protein related to the class III subfamily of receptor tyrosine kinases (RTK), the platelet-derived growth factor receptors (1-5). PDGFRL is a tumor suppressor active in the tumor-suppression network and implicated in colorectal cancer, and a decrease in PDGFRL expression levels has been observed in breast cancer (1). A variant of PDGFRL is found to play a role in the development of Behçet disease, a complex immunoregulatory disease (6). The autoimmune role of PDGFRL is also supported by its up-regulation in a mouse model for Rheumatoid Arthritis (7). Study also showed that PDGFRL may play a role in chondrocyte proliferation and differentiation.

1. Guo, F-J. et al. (2010) World J Gastroenterol. 16:1465.
2. Andrae, J. et al. (2008) Genes Dev. 22:1276.
3. Heldin, C-H. and B. Westermark (1999) Physiol. Rev. 79:1283.
4. Claesson-Welsh, L. et al. (1989) Proc. Natl. Acad. Sci. USA 86:4917.
5. Matsui, T. et al. (1989) Science 243:800.
6. Hou, S. et al. (2013). Human Mutat. 34:74.
7. Fujikado, N. et al. (2006). Arthritis Res. & Ther. 8:R100.
8. Kawata, K. et al. (2017) J Cell Biochemistry. 118:4033.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.