Universal Type I IFN Protein

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Product Details

Summary
Reactivity HuSpecies Glossary

Order Details

Universal Type I IFN Protein Summary

Additional Information
(Recombinant Human IFN-alpha A/D [BglII])
Protein/Peptide Type
Recombinant Proteins
Gene
IFNA2

Applications/Dilutions

Publications
Read Publications using
11200-2 in the following applications:

Packaging, Storage & Formulations

Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Universal Type I IFN Protein

  • IFNA
  • IFNA2
  • IFNA2b
  • IFNalpha
  • IFN-alpha
  • IFN-alphaA
  • INFA2
  • interferon alpha 2
  • LeIF D

Background

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

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Publications for IFN-alpha (11200-2)(31)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Bioassay, Cell Culture, In Vivo.


Filter By Application
Bioassay
(26)
Cell Culture
(3)
In Vivo
(2)
All Applications
Filter By Species
Human
(29)
Mouse
(2)
All Species
Showing Publications 1 - 10 of 31. Show All 31 Publications.
Publications using 11200-2 Applications Species
Ikeda, T;Shimizu, R;Nasser, H;Carpenter, MA;Cheng, AZ;Brown, WL;Sauter, D;Harris, RS; APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1 mBio 2023-08-09 [PMID: 37555667] (Bioassay, Human) Bioassay Human
J Song, RD Chow, M Pena-Herna, L Zhang, SA Loeb, EY So, OD Liang, P Ren, S Chen, CB Wilen, S Lee LRRC15 inhibits SARS-CoV-2 cellular entry in trans PloS Biology, 2022-10-13;20(10):e3001805. 2022-10-13 [PMID: 36228039] (Bioassay, Human) Bioassay Human
B Los, M Preu beta ner, K Eschke, RM Vidal, A Abdelgawad, D Olofsson, S Keiper, M Paulo-Pedr, A Grindel, S Meinke, J Trimpert, F Heyd Body temperature variation controls pre-mRNA processing and transcription of antiviral genes and SARS-CoV-2 replication Nucleic Acids Research, 2022-07-08;0(0):. 2022-07-08 [PMID: 35713540] (Bioassay, Human) Bioassay Human
X Yang, X Zhao, Y Zhu, Y Shen, Y Wang, P Lu, Z Jiang, H Pan, J Yang, J Xun, L Zhao, J Wang, Z Liang, X Shen, Y Liang, Q Lin, H Liang, L Jin, D Zhang, J Liu, B Wang, S Jiang, J Xu, H Wu, H Lu, H Zhu FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat MBio, 2021-07-20;0(0):e0079521. 2021-07-20 [PMID: 34281390] (Bioassay, Human) Bioassay Human
N Buang, L Tapeng, V Gray, A Sardini, C Whilding, L Lightstone, TD Cairns, MC Pickering, J Behmoaras, GS Ling, M Botto Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus Nature Communications, 2021-03-31;12(1):1980. 2021-03-31 [PMID: 33790300] (Bioassay, Human) Bioassay Human
KP Singh, JM Zerbato, W Zhao, S Braat, C Deleage, GS Tennakoon, H Mason, A Dantanaray, A Rhodes, JW Rhodes, J Torresi, AN Harman, PA Revill, M Crane, JD Estes, A Avihingsan, SR Lewin, J Audsley Intrahepatic CXCL10 is strongly associated with liver fibrosis in HIV-Hepatitis B co-infection PLoS Pathog., 2020-09-08;16(9):e1008744. 2020-09-08 [PMID: 32898182] (Bioassay, Human) Bioassay Human
C Paulus, T Harwardt, B Walter, A Marxreiter, M Zenger, E Reuschel, MM Nevels Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early protein 1 PLoS Pathog., 2020-05-04;16(5):e1008537. 2020-05-04 [PMID: 32365141] (Cell Culture, Human) Cell Culture Human
RM Van der Sl, JM Zerbato, JW Rhodes, RD Pascoe, A Solomon, NA Kumar, AI Dantanaray, S Tennakoon, J Dufloo, J McMahon, JJ Chang, VA Evans, PJ Hertzog, MR Jakobsen, AN Harman, SR Lewin, PU Cameron Diverse effects of interferon alpha on the establishment and reversal of HIV latency PLoS Pathog., 2020-02-28;16(2):e1008151. 2020-02-28 [PMID: 32109259] (Cell Culture, Human) Cell Culture Human
E Kuca-Warna, U Skalska, I Janicka, U Musia?owic, K Bonek, P G?uszko, P Szcz?sny, M Olesi?ska, E Kontny The Phenotype and Secretory Activity of Adipose-Derived Mesenchymal Stem Cells (ASCs) of Patients with Rheumatic Diseases Cells, 2019-12-17;8(12):. 2019-12-17 [PMID: 31861245] (Cell Culture, Human) Cell Culture Human
F Vahedi, AJ Lee, SE Collins, MV Chew, E Lusty, B Chen, A Dubey, CD Richards, JJ Feld, RS Russell, KL Mossman, AA Ashkar IL-15 and IFN-? signal through the ERK pathway to inhibit HCV replication, independent of type I IFN signaling Cytokine, 2018-06-19;0(0):. 2018-06-19 [PMID: 29908921] (Bioassay, Human) Bioassay Human
Show All 31 Publications.

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Blogs on IFN-alpha.

STING in Innate Immunity and Cancer: What’s the Buzz About?
STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also ...  Read full blog post.

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Bioinformatics

Gene Symbol IFNA2