Universal Type I IFN Protein

• Reactivity: Hu

Universal Type I IFN Protein Summary

• Additional Information: (Recombinant Human IFN-alpha A/D [BglII])
• Protein/Peptide Type: Recombinant Proteins
• Gene: IFNA2

Applications/Dilutions

Publications

Read Publications using 11200-2 in the following applications: Bioassay 26 publications Cell Culture 3 publications In Vivo 2 publications

Packaging, Storage & Formulations

• Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Universal Type I IFN Protein

• IFNA
• IFNA2
• IFNA2b
• IFNalpha
• IFN-alpha
• IFN-alphaA
• INFA2
• interferon alpha 2
• LeIF D

Background

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Publications for IFN-alpha (11200-2)(31)

Publications using 11200-2

• Ikeda, T;Shimizu, R;Nasser, H;Carpenter, MA;Cheng, AZ;Brown, WL;Sauter, D;Harris, RS; APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1 mBio 2023-08-09 [PMID: 37555667] (Bioassay, Human)
• J Song, RD Chow, M Pena-Herna, L Zhang, SA Loeb, EY So, OD Liang, P Ren, S Chen, CB Wilen, S Lee LRRC15 inhibits SARS-CoV-2 cellular entry in trans PloS Biology, 2022-10-13;20(10):e3001805. 2022-10-13 [PMID: 36228039] (Bioassay, Human)
• B Los, M Preu beta ner, K Eschke, RM Vidal, A Abdelgawad, D Olofsson, S Keiper, M Paulo-Pedr, A Grindel, S Meinke, J Trimpert, F Heyd Body temperature variation controls pre-mRNA processing and transcription of antiviral genes and SARS-CoV-2 replication Nucleic Acids Research, 2022-07-08;0(0):. 2022-07-08 [PMID: 35713540] (Bioassay, Human)
• X Yang, X Zhao, Y Zhu, Y Shen, Y Wang, P Lu, Z Jiang, H Pan, J Yang, J Xun, L Zhao, J Wang, Z Liang, X Shen, Y Liang, Q Lin, H Liang, L Jin, D Zhang, J Liu, B Wang, S Jiang, J Xu, H Wu, H Lu, H Zhu FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat MBio, 2021-07-20;0(0):e0079521. 2021-07-20 [PMID: 34281390] (Bioassay, Human)
• N Buang, L Tapeng, V Gray, A Sardini, C Whilding, L Lightstone, TD Cairns, MC Pickering, J Behmoaras, GS Ling, M Botto Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus Nature Communications, 2021-03-31;12(1):1980. 2021-03-31 [PMID: 33790300] (Bioassay, Human)
• KP Singh, JM Zerbato, W Zhao, S Braat, C Deleage, GS Tennakoon, H Mason, A Dantanaray, A Rhodes, JW Rhodes, J Torresi, AN Harman, PA Revill, M Crane, JD Estes, A Avihingsan, SR Lewin, J Audsley Intrahepatic CXCL10 is strongly associated with liver fibrosis in HIV-Hepatitis B co-infection PLoS Pathog., 2020-09-08;16(9):e1008744. 2020-09-08 [PMID: 32898182] (Bioassay, Human)
• C Paulus, T Harwardt, B Walter, A Marxreiter, M Zenger, E Reuschel, MM Nevels Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early protein 1 PLoS Pathog., 2020-05-04;16(5):e1008537. 2020-05-04 [PMID: 32365141] (Cell Culture, Human)
• RM Van der Sl, JM Zerbato, JW Rhodes, RD Pascoe, A Solomon, NA Kumar, AI Dantanaray, S Tennakoon, J Dufloo, J McMahon, JJ Chang, VA Evans, PJ Hertzog, MR Jakobsen, AN Harman, SR Lewin, PU Cameron Diverse effects of interferon alpha on the establishment and reversal of HIV latency PLoS Pathog., 2020-02-28;16(2):e1008151. 2020-02-28 [PMID: 32109259] (Cell Culture, Human)
• E Kuca-Warna, U Skalska, I Janicka, U Musia?owic, K Bonek, P G?uszko, P Szcz?sny, M Olesi?ska, E Kontny The Phenotype and Secretory Activity of Adipose-Derived Mesenchymal Stem Cells (ASCs) of Patients with Rheumatic Diseases Cells, 2019-12-17;8(12):. 2019-12-17 [PMID: 31861245] (Cell Culture, Human)
• F Vahedi, AJ Lee, SE Collins, MV Chew, E Lusty, B Chen, A Dubey, CD Richards, JJ Feld, RS Russell, KL Mossman, AA Ashkar IL-15 and IFN-? signal through the ERK pathway to inhibit HCV replication, independent of type I IFN signaling Cytokine, 2018-06-19;0(0):. 2018-06-19 [PMID: 29908921] (Bioassay, Human)
• K Matsuno, M Kajihara, R Nakao, N Nao, A Mori-Kajih, M Muramatsu, Y Qiu, S Torii, M Igarashi, N Kasajima, K Mizuma, K Yoshii, H Sawa, C Sugimoto, A Takada, H Ebihara The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus mSphere, 2018-06-13;3(3):. 2018-06-13 [PMID: 29898985] (Bioassay, Human)
• U Cytlak, A Resteu, D Bogaert, HS Kuehn, T Altmann, A Gennery, G Jackson, A Kumanovics, KV Voelkerdin, S Prader, M Dullaers, J Reichenbac, H Hill, F Haerynck, SD Rosenzweig, M Collin, V Bigley Ikaros family zinc finger 1 regulates dendritic cell development and function in humans Nat Commun, 2018-03-27;9(1):1239. 2018-03-27 [PMID: 29588478] (Bioassay, Human)
• X Dai, M Tohyama, M Murakami, K Sayama Epidermal keratinocytes sense dsRNA via the NLRP3 inflammasome, mediating interleukin (IL)-1? and IL-18 release Exp. Dermatol, 2017-05-12;0(0):. 2017-05-12 [PMID: 28266737] (Bioassay, Human)
• Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer Nature, 2016-05-18;533(7604):493-8. 2016-05-18 [PMID: 27225120] (Bioassay, Human)
• JF Hedges, A Robison, E Kimmel, K Christense, E Lucas, A Ramstead, MA Jutila Type I IFN counters or promotes Coxiella burnetii replication dependent on tissue Infect Immun, 2016-05-24;0(0):. 2016-05-24 [PMID: 27068091] (In Vivo, Mouse)
• Labzin L, Schmidt S, Masters S, Beyer M, Krebs W, Klee K, Stahl R, Lutjohann D, Schultze J, Latz E, De Nardo D ATF3 Is a Key Regulator of Macrophage IFN Responses. J Immunol, 2015-09-28;195(9):4446-55. 2015-09-28 [PMID: 26416280] (Bioassay, Human)
• Berri F, Haffar G, Le V, Sadewasser A, Paki K, Lina B, Wolff T, Riteau B Annexin V incorporated into influenza virus particles inhibits gamma interferon signaling and promotes viral replication. J Virol, 2014-07-16;88(19):11215-28. 2014-07-16 [PMID: 25031344] (Bioassay, Human)
• Cimica V, Dalrymple N, Roth E, Nasonov A, Mackow E An innate immunity-regulating virulence determinant is uniquely encoded by the Andes virus nucleocapsid protein. MBio, 2014-02-18;5(1):. 2014-02-18 [PMID: 24549848] (Bioassay, Human)
• Ray A, Tian Z, Das D, Coffman R, Richardson P, Chauhan D, Anderson K A novel TLR-9 agonist C792 inhibits plasmacytoid dendritic cell-induced myeloma cell growth and enhance cytotoxicity of bortezomib. Leukemia, 2014-01-30;28(8):1716-24. 2014-01-30 [PMID: 24476765] (Bioassay, Human)
• Li X, Jiang L, Chen L, Ding M, Guo H, Zhang W, Zhang H, Ma X, Liu X, Xi X, Chen S, Chen Z, Zhu J RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness. Mol Cell, 2014-01-09;53(3):407-19. 2014-01-09 [PMID: 24412064] (Bioassay, Human)
• Li W, Okuda A, Yamamoto H, Yamanishi K, Terada N, Yamanishi H, Tanaka Y, Okamura H Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18. PLoS ONE, 2013-12-20;8(12):e82586. 2013-12-20 [PMID: 24376549] (Bioassay, Human)
• Wang T, Ge Y, Xiao M, Lopez-Coral A, Li L, Roesch A, Huang C, Alexander P, Vogt T, Xu X, Hwang W, Lieu M, Belser E, Liu R, Somasundaram R, Herlyn M, Kaufman R SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway. J Invest Dermatol, 2013-10-24;134(4):1108-18. 2013-10-24 [PMID: 24157461] (Bioassay, Human)
• Webster , Brian, Ott , Melanie, Greene , Warner C Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus. J Virol, 2013-10-02;87(24):13354-69. 2013-10-02 [PMID: 24089557] (Bioassay, Human)
• Chen , Qian, Swaminathan , Sanjay, Yang , De, Dai , Lue, Sui , Hongyan, Yang , Jun, Hornung , Ronald L, Wang , Yanmei, Huang , Da Wei, Hu , Xiaojun, Lempicki , Richard, Imamichi , Tomozumi Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway. PLoS ONE, 2013-03-20;8(3):e59194. 2013-03-20 [PMID: 23527130] (Bioassay, Human)
• Rosen L, Freeman A, Yang L, Jutivorakool K, Olivier K, Angkasekwinai N, Suputtamongkol Y, Bennett J, Pyrgos V, Williamson P, Ding L, Holland S, Browne S Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis. J Immunol, 2013-03-18;190(8):3959-66. 2013-03-18 [PMID: 23509356] (Bioassay, Human)
• Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients. Clin Cancer Res, 2013-02-26;19(7):1858-72. 2013-02-26 [PMID: 23444227] (Bioassay, Human)
• Jones P, Maric M, Madison M, Maury W, Roller R, Okeoma C BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1). Virology, 2013-02-12;438(1):37-49. 2013-02-12 [PMID: 23411007] (Bioassay, Human)
• Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)
• Cilloniz C, Pantin-Jackwood MJ, Ni C, Carter VS, Korth MJ, Swayne DE, Tumpey TM, Katze MG Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival. J. Virol., 2011-12-21;86(5):2437-46. 2011-12-21 [PMID: 22190720] (In Vivo, Mouse)
• Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma. PLoS Pathog., 2011-04-14;7(4):e1002016. 2011-04-14 [PMID: 21533215] (Bioassay, Human)
• Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J. Exp. Med., 2008-12-29;206(1):249-58. 2008-12-29 [PMID: 19114666] (Bioassay, Human)

Bioinformatics

• Gene Symbol: IFNA2