PDE6G Antibody (OTI2F5) [Janelia Fluor® 525]

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clone: OTI2F5
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 525

PDE6G Antibody (OTI2F5) [Janelia Fluor® 525] Summary

• Immunogen: Full length human recombinant protein of human PDE6G(NP_002593) produced in HEK293T cell.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: PDE6G
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for PDE6G Antibody (OTI2F5) [Janelia Fluor® 525]

• DKFZp686C0587
• GMP-PDE gamma
• MGC125749
• PDE6G
• PDEG
• phosphodiesterase 6G, cGMP-specific, rod, gamma
• retinal rod rhodopsin-sensitive cGMP 3'-5'-cyclic phosphodiesterase subunit gamma
• rod cG-PDE G
• RP57

Background

PDE6G encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. PDE6G is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. PDE6G is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PDE6G