Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Immunogen affinity purified
Western Blot 1:100-1:2000
IF: Use at an assay dependent dilution. IHC-P: Use at an assay dependent dilution. WB: Use at a concentration of 2 ug/ml. Detects a band of approximately 90 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
Read 1 Review rated 4 using NB120-5663 in the following applications:
Expected to cross react with PDE6B. Not yet tested in other species.
Alternate Names for PDE6 beta Antibody
PDEBrod cGMP-phosphodiesterase beta-subunit
phosphodiesterase 6B, cGMP-specific, rod, beta
rod cGMP-specific 3'-5'-cyclic phosphodiesterase subunit beta
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.