PCDHA6 Antibody

Images

 
Immunohistochemistry: PCDHA6 Antibody [NBP2-69060] - Immunohistochemical staining of human cerebellum shows moderate cytoplasmic positivity in cells in molecular layer.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

PCDHA6 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: PSLSPCPIMMGKAENQDLNEDHDAKV
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PCDHA6
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:1000 - 1:2500
  • Immunohistochemistry-Paraffin 1:1000 - 1:2500
Application Notes
Recommended conditions for IHC,Retrieval method: HIER pH6

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Protein A purified

Alternate Names for PCDHA6 Antibody

  • CNR2
  • CNRN2
  • CNRS2
  • CRNR2
  • KIAA0345-like 8
  • PCDH-ALPHA6
  • PCDH-alpha-6
  • protocadherin alpha 6
  • protocadherin alpha-6

Background

PCDHA6 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PCDHA6