PCDHA6 Products

Description

PCDHA6 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Bioinformatics

Uniprot	NM_018909 Human NP_061732 Human NP_061732.1 Human Q9UN73 Human Q9UN73-3 Human
Product By Gene ID	56142
Alternate Names	CNR2 CNRN2 CNRS2 CRNR2 KIAA0345-like 8 PCDH-ALPHA6 PCDH-alpha-6 protocadherin alpha 6 protocadherin alpha-6