PAWR / PAR4 Antibody [DyLight 650]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 650

PAWR / PAR4 Antibody [DyLight 650] Summary

• Immunogen: Synthetic peptides corresponding to the N-terminal sequence (MATGGYRTSSGLGGS) and C-terminal sequence (QENKTLLKVVGQLTR) of human PAR4.
• Localization: Cytoplasm. Nucleus. Note: Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML n
• Specificity: PAR4
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PAWR
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Human. Other species have not been tested.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for PAWR / PAR4 Antibody [DyLight 650]

• Par-4
• PAR4prostate apoptosis response protein 4
• PRKC apoptosis WT1 regulator protein
• PRKC, apoptosis, WT1, regulator
• Prostate apoptosis response 4 protein
• prostate apoptosis response protein PAR-4
• transcriptional repressor PAR4
• WT1-interacting protein

Background

The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PAWR