PAPSS2 Antibody - BSA Free

Immunohistochemistry-Paraffin: PAPSS2 Antibody [NBP3-17062] - Staining of human cartilage shows strong nuclear positivity in the chondrocytes.

Immunohistochemistry-Paraffin: PAPSS2 Antibody [NBP3-17062] - Analysis in human adrenal gland and cerebellum tissues using Anti-PAPSS2 antibody. Corresponding PAPSS2 RNA-seq data are presented for the same tissues.

Immunohistochemistry-Paraffin: PAPSS2 Antibody [NBP3-17062] - Staining of human adrenal gland shows high expression.

Immunohistochemistry-Paraffin: PAPSS2 Antibody [NBP3-17062] - Staining of human cerebellum shows low expression as expected.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

PAPSS2 Antibody - BSA Free Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: DTLLDGMALPDGVINMSIPIVLPVSAEDKTR
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PAPSS2
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, pH 7.2, 40% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for PAPSS2 Antibody - BSA Free

• 3'-phosphoadenosine 5'-phosphosulfate synthase 2
• ATP sulfurylase/adenosine 5'-phosphosulfate kinase
• ATPSK2ATP sulfurylase/APS kinase 2
• bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
• bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2
• EC 2.7.1.25
• PAPS synthase 2
• PAPS synthetase 2
• PAPSS 2
• SK 2
• SK2
• Sulfurylase kinase 2,3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 2

Background

Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PAPSS2