Recombinant Human Osteoprotegerin/TNFRSF11B Protein

Product Discontinued

Recombinant Human Osteoprotegerin/TNFRSF11B Protein Summary

• Description: Recombinant bioactive protein containing 174 amino acids for Human Osteoprotegerin/TNFRSF11B
  
  

  Source:E. coli
  Amino Acid Sequence:(O14790)

• Preparation Method: Determined to be >98% pure by SDS-PAGE
• Details of Functionality: Determined by its ability to neutralize the stimulation of U937 cells treated with 10 ng/ml of sRANKL.
• Source: E. coli
• Protein/Peptide Type: Recombinant Protein
• Gene: TNFRSF11B
• Purity: >98%, by SDS-PAGE
• Endotoxin Note: <0.1 ng/ug

Applications/Dilutions

• Dilutions:
  • Bioactivity
  • SDS-Page
• Theoretical MW: 20 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20 to -80C. Avoid freeze-thaw cycles.
• Buffer: Sterile filtered and then lyophilized
• Concentration: Lyoph
• Purity: >98%, by SDS-PAGE
• Reconstitution Instructions: Reconstitute in 5 mM Tris, pH 7.5 to a concentration of 0.1 - 1.0 mg/ml. The solution can be diluted into other aqueous buffers andstored at 4C for 1 week or -20C for long-term storage.

Alternate Names for Recombinant Human Osteoprotegerin/TNFRSF11B Protein

• OCIF
• OCIFMGC29565
• OPG
• OPGtumor necrosis factor receptor superfamily member 11B
• Osteoclastogenesis inhibitory factor
• Osteoprotegerin
• TNFRSF11B
• TR1
• tumor necrosis factor receptor superfamily, member 11b

Background

Human OPG (Osteoprotegerin), also known as OCIF (Osteoclastogenesis inhibitory factor), is a member of the TNF receptor superfamily. Recombinant human OPG/OCIF specifically acts on bone tissues and increases bone mineral density and bone volume associated with a decrease of active osteoclast number. Recombinant human OPG is a 20 kDa protein, comprising of 174 amino acid residues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: TNFRSF11B