ORC1 Antibody (7F6/1) [Janelia Fluor® 585]

Product Discontinued

ORC1 Antibody (7F6/1) [Janelia Fluor® 585] Summary

• Immunogen: Recombinant full-length human ORC1 protein (Uniprot: Q13415)
• Localization: Nucleus.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: ORC1
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for ORC1 Antibody (7F6/1) [Janelia Fluor® 585]

• HS
• HSORC1
• ORC1Lorigin recognition complex subunit 1
• origin recognition complex, subunit 1 (yeast homolog)-like
• origin recognition complex, subunit 1 homolog (S. cerevisiae)
• origin recognition complex, subunit 1 homolog
• origin recognition complex, subunit 1
• origin recognition complex, subunit 1-like (yeast)
• origin recognition complex, subunit 1-like
• PARC1origin recognition complex 1
• Replication control protein 1

Background

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ORC1