OCIL/CLEC2d Antibody (166C1309)

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Western Blot: OCIL/CLEC2d Antibody (166C1309) [NB100-56553] - Analysis of OCIL in mouse spleen cell lysates. Thirty microgram of cell lysates per lane of mini gel.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clone
166C1309
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.5 mg/ml

OCIL/CLEC2d Antibody (166C1309) Summary

Immunogen
This antibody was developed by immunizing mice with a synthetic peptide containing amino acids 2-18 (CVTKASLPMLSPTGSPQ) of mouse OCIL, GenBank no. gb|AAL37198.1.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CLEC2D
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot
Positive Control
Spleen Lysate (NB820-59670)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.2% gelatin
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for OCIL/CLEC2d Antibody (166C1309)

  • CLAXLLT-1
  • CLEC2D
  • C-type lectin domain family 2 member D
  • C-type lectin domain family 2, member D
  • C-type lectin related f
  • Lectin-like NK cell receptor
  • Lectin-like transcript 1
  • LLT1
  • LLT1Osteoclast inhibitory lectin
  • OCIL
  • OCILmember D

Background

Recently, Zhou et al have identified a protein that can inhibit multinucleate Osteoclast formation in murine osteoblast and spleen cell co-cultures. This protein called, Osteoclast Inhibitory Lectin (OCIL) can also inhibit osteoclast formation in spleen cell cultures treated with RANKL and M-CSF. Furthermore, mOCIL acted directly on macrophage/monocyte cells as evidenced by its inhibitory action on adherent spleen cell cultures, which were depleted of stromal and lymphocytic cells. mOCIL completely inhibited osteoclast formation during the proliferative phase of osteoclast formation and resulted in 70% inhibition during the differentiation phase. Osteoblast OCIL mRNA expression was enhanced by parathyroid hormone, calcitriol, interleukin-1 and IL-11, and retinoic acid. OCIL is expressed in osteoblasts and chondrocytes as well as in a variety of extraskeletal tissues. Since OCIL expression was found to be very similar to distribution for RANKL, it has been suggested that RANKl and OCIL may interact in skeleton and in extracellular tissues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB100-56553AF405
Alexa Fluor 488 Labeled NB100-56553AF488
Alexa Fluor 647 Labeled NB100-56553AF647
Alexa Fluor 700 Labeled NB100-56553AF700
Biotin Labeled NB100-56553B
DyLight 350 Labeled NB100-56553UV
DyLight 405 Labeled NB100-56553V
DyLight 488 Labeled NB100-56553G
DyLight 550 Labeled NB100-56553R
DyLight 650 Labeled NB100-56553C
DyLight 680 Labeled NB100-56553FR
DyLight 755 Labeled NB100-56553IR
HRP Labeled NB100-56553H

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Diseases for OCIL/CLEC2d Antibody (NB100-56553)

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PTMs for OCIL/CLEC2d Antibody (NB100-56553)

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Bioinformatics

Gene Symbol CLEC2D
Entrez
Uniprot