Numb Antibody Blocking Peptide

Product Discontinued

Numb Antibody Blocking Peptide Summary

• Description: A blocking peptide containing 17 amino acids near the carboxy terminus of human NUMB.

  Source: Synthetic

  (Accession #: NP_1005743)

• Source: Synthetic
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: NUMB
• Purity: N/A

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NBP1-76576.
  
  For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
• Preservative: 0.02% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: N/A

Alternate Names for Numb Antibody Blocking Peptide

• h-Numb
• mnb
• m-numb
• numb (Drosophila) homolog
• numb homolog (Drosophila)
• Numb
• protein numb homolog
• Protein S171
• S171

Background

Numb is a transmembrane signaling receptor that is activated by the DSL family of ligands. Studies suggestthat mammalian Numb plays a role in progenitor cell fate in neurogenesis. Numb exerts its role on cell fate by antagonizing Notch signaling. The mammalian Numb gene undergoes alternative splicing to produce at least four functionally different Numb isoforms which regulate different processes. A loss of Numb expression has been demonstrated in breast cancer, non-small cell lung cancer and chronic myelogenous leukemia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: NUMB