Numb Products

Antibodies
Lysates
Numb Overexpression Lysate
Numb Overexpression Lysate
NBP2-08848
Species: Hu
Applications: WB
Numb Overexpression Lysate
Numb Overexpression Lysate
NBL1-13870
Species: Hu
Applications: WB
Numb Overexpression Lysate
Numb Overexpression Lysate
NBP2-08847
Species: Hu
Applications: WB
Proteins
Numb Antibody Blocking Peptid ...
Numb Antibody Blocking Peptide
NB500-178PEP
Species: Mu
Applications: AC
Recombinant Human Numb GST (N ...
Recombinant Human Numb GST (N-Term...
H00008650-P01
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP

Description

Numb is a transmembrane signaling receptor that is activated by the DSL family of ligands. Studies suggestthat mammalian Numb plays a role in progenitor cell fate in neurogenesis. Numb exerts its role on cell fate by antagonizing Notch signaling. The mammalian Numb gene undergoes alternative splicing to produce at least four functionally different Numb isoforms which regulate different processes. A loss of Numb expression has been demonstrated in breast cancer, non-small cell lung cancer and chronic myelogenous leukemia.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Human
Human
Mouse
Product By Gene ID 8650
Alternate Names
  • Protein S171
  • protein numb homolog
  • numb (Drosophila) homolog
  • S171
  • h-Numb
  • numb homolog (Drosophila)

Research Areas for Numb

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Growth and Development
Neuronal Cell Markers
Neuroscience
Stem Cell Markers
Stem Cell Signaling Pathway

Bioinformatics Tool for Numb

Discover related pathways, diseases and genes to Numb. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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