NRAMP1/SLC11A1 Antibody (910825)

Images

 
Western blot shows lysates of HEK293 human embryonic kidney cell line either mock transfected or transfected with human NRAMP1/SLC11A1. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human NRAMP1/SLC11A1 ...read more
HEK293 human embryonic kidney cell line transfected with either (A) human NRAMP1/SLC11A1 or (B) irrelevant transfectants and eGFP was stained with Mouse Anti-Human NRAMP1/SLC11A1 Monoclonal Antibody (Catalog # MAB8400) ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clone
910825
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

NRAMP1/SLC11A1 Antibody (910825) Summary

Immunogen
NS0 mouse myeloma cell line transfected with human NRAMP1/SLC11A1
Met1-Gly550
Accession # NP_000569
Specificity
Detects HEK293 human embryonic kidney cell line transfected with human NRAMP1/SLC11A1 by Flow Cytometry. Does not detect untransfected or irrelevant transfected HEK293 cells.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
SLC11A1
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • Flow Cytometry 0.25 ug/10^6 cells
  • CyTOF-ready

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NRAMP1/SLC11A1 Antibody (910825)

  • natural resistance-associated macrophage protein 1
  • LSH
  • member 1
  • NRAMP 1
  • NRAMP1
  • NRAMP1solute carrier family 11 (sodium/phosphate symporters), member 1
  • NRAMPnatural resistance-associated macrophage protein 1
  • SLC11A1
  • solute carrier family 11 (proton-coupled divalent metal ion transporters)

Background

NRAMP1/SLC11A1 (Natural Resistance-Associated Macrophage Protein 1/Solute Carrier family 11, member 1) is a member of the solute carrier family of multi-pass membrane proteins. It functions as a proton-coupled divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in SLC11A1 have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn’s disease. Alternatively spliced variants that encode different protein isoforms have been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for NRAMP1/SLC11A1 Antibody (MAB8400) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB8400U
Alexa Fluor 405 FAB8400V
Alexa Fluor 488 FAB8400G
Alexa Fluor 594 FAB8400T
Alexa Fluor 647 FAB8400R
Alexa Fluor 700 FAB8400N
Alexa Fluor 750 FAB8400S
Allophycocyanin FAB8400A

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Bioinformatics

Gene Symbol SLC11A1
Uniprot