NLRP2/NALP2 Antibody [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 350

NLRP2/NALP2 Antibody [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human NLRP2/NALP2
  Met1-Thr208
  Accession # Q9NX02
• Specificity: Detects human NLRP2/NALP2 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NLRP2/NALP2 Antibody [Alexa Fluor® 350]

• CLR19.9
• FLJ20510
• NACHT, leucine rich repeat and PYD containing 2
• NACHT, LRR and PYD domains-containing protein 2
• NALP2
• NALP2NACHT, LRR and PYD containing protein 2
• NBS1
• NBS1PYRIN-containing APAF1-like protein 2
• NLR family, pyrin domain containing 2
• NLRP2
• nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 2
• PAN1
• PAN1Nucleotide-binding site protein 1
• PYPAF2
• PYPAF2PYRIN domain and NACHT domain-containing protein 1

Background

NALP2 (NAcht Leucine-rich repeat Protein 2, also known as NLRP2 and PAN1) is a cytosolic, 121 kDa member of the NLRP family of proteins. It is expressed in macrophages and exhibits divergent effects on inflammation. Via NF kappa B, it suppresses TNF-alpha production in response to LPS; via procaspase-1, it promotes proIL-1 beta cleavage and release. Human NALP2 is 1062 amino acids (aa) in length. It contains an N-terminal Pyrin domain (aa 9‑90), followed by a Nacht region and nine LRRs (aa 467‑1033). Four alternate isoforms exist. Three show deletions of aa’s 109‑132, 133‑154 and 847‑1062, respectively; a fourth shows a 38 aa substitution for aa’s 1‑903. No close rodent counterparts have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.