Neuregulin-1/NRG1 Antibody

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Western Blot: Neuregulin-1/NRG1 Antibody [NBP2-19587] - Rat tissue extract (50 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Neuregulin-1 antibody diluted at 1:1000.
Immunocytochemistry/ Immunofluorescence: Neuregulin-1/NRG1 Antibody [NBP2-19587] - SK-N-SH cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Neuregulin-1 protein stained by Neuregulin-1 antibody diluted ...read more
Western Blot: NRG1 Antibody [NBP2-19587] - Sample (50 ug of whole cell lysate) A: Mouse Brain, 7. 5% SDS PAGE gel, diluted at 1:1000.
Western Blot: Neuregulin-1/NRG1 Antibody [NBP2-19587] - Human tissue extract (30 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Neuregulin-1 antibody diluted at 1:1000.
Western Blot: Neuregulin-1/NRG1 Antibody [NBP2-19587] - U87-MG whole cell extract and conditioned medium (30ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with Neuregulin-1 antibody diluted at 1:1000.

Product Details

Summary
Reactivity Hu, Mu, Rt, BvSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Neuregulin-1/NRG1 Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human NRG1. The exact sequence is proprietary.
Localization
Pro-neuregulin-1; membrane-bound isoform: Cell membrane; Single-pass type I membrane protein; Neuregulin-1: Secreted; Isoform 8: Nucleus; Isoform 9: Secreted; Isoform 10: Membrane; Single-pass type I membrane protein
Predicted Species
Bovine (91%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NRG1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunocytochemistry/Immunofluorescence 1:100-1:1000
Theoretical MW
70 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
Neuregulin-1/NRG1 Lysate (NBP2-66241)

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Purity
Immunogen affinity purified

Alternate Names for Neuregulin-1/NRG1 Antibody

  • ARIA
  • GGF2
  • GGFglial growth factor
  • Heregulin-1
  • HGL
  • HGLneu differentiation factor
  • HRG
  • HRG1
  • HRG1-alpha
  • HRG1-beta 1
  • HRGAneuregulin 1 type IV beta 1a
  • MST131
  • MSTP131
  • NDFheregulin, alpha (45kD, ERBB2 p185-activator)
  • neuregulin 1 type IV beta 3
  • neuregulin 1
  • Neuregulin1
  • Neuregulin-1
  • NRG1
  • pro-neuregulin-1, membrane-bound isoform
  • pro-NRG1
  • sensory and motor neuron derived factor
  • SMDF

Background

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol NRG1
Entrez
Uniprot