Netrin-1 Antibody

Product Discontinued

Netrin-1 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 501-550 of Human Netrin-1.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NTN1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000
• Theoretical MW: 68 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse and Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Netrin-1 Antibody

• netrin 1
• Netrin1
• Netrin-1
• NTN1
• NTN1Lnetrin 1, mouse, homolog of

Background

Netrin-G1 ligand (NGL1) is a transmembrane protein containing leucine-rich repeat (LRR) and immunoglobulin (Ig) domains that specifically interact with netrin-G1 through its LRR region. Whereas netrin-G1 is expressed highly in mouse thalamic axons, NGL1 is most abundant in the striatum and the cerebral cortex. NGL1 is implicated in facilitating axonal growth of the vertebrate CNS. Membrane-bound netrin-G1 acts as an axonal receptor, whereas the LRR-containing transmembrane protein NGL1 acts as a ligand in promoting the growth of thalamic axons.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Netrin-1 Antibody (NBP1-19822)(1)

Publication using NBP1-19822

• Akino T, Han X, Nakayama H et al. Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and demonstrates elevated expression in tumor tissue and urine of pediatric medulloblastoma patients. Cancer Res. 2014-05-08 [PMID: 24812271] (IHC-P, WB, Human)

Bioinformatics

• Gene Symbol: NTN1
• Entrez:
  • 9423(Human)
  • 18208(Mouse)
  • 114523(Rat)
• Uniprot:
  • O95631()