Netrin-1 Products

Antibodies
Netrin-1 Antibody
Netrin-1 Antibody
NB100-1605
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
Host: Chicken Polyclonal
Netrin-1 Antibody (158936) [U ...
Netrin-1 Antibody (158936) [Unconj...
MAB1109
Species: Mu
Applications: WB
Host: Rat Monoclonal
Netrin-1 Antibody (Nora-1)
Netrin-1 Antibody (Nora-1)
NBP1-97641
Species: Hu, Mu, Ch, Xp
Applications: WB, ELISA, IHC, IHC-P, IP
Host: Mouse Monoclonal
Proteins
Netrin-1 Partial Recombinant ...
Netrin-1 Partial Recombinant Protein
H00009423-Q01
Species: Hu
Applications: WB, ELISA, PA
Netrin-1 Recombinant Protein ...
Netrin-1 Recombinant Protein Antigen
NBP2-31640PEP
Species: Hu
Applications: AC

Description

Semaphorins, neuropilins and netrins are among a number of molecules and their receptors that regulate the developing nervous system to guide the development of neural circuits.1 Although first identified as axon guidance cues,2,3 it is now apparent that many of these same factors are not limited to the guidance of growing axons, but have roles in a range of processes from the guidance of cell migration to the regulation of the immune response, angiogenesis, lung branching morphogenesis, nervous system regeneration, and cancer.4-9 The semaphorins make up the largest family of axon guidance cues. They are characterized by the presence of an approximately 500 amino acid N-terminal semaphorin (Sema) domain. Semaphorins function mainly as chemorepellents that direct axons away from tissues.3 Semaphorin 3A (Sema3A) has been shown to be repellent to cortical axons and to inhibit axon branching.10 The transmembrane protein semaphorin 6A has been shown to repel embryonic sympathetic axons.11 The actions of the various semaphorins are not always similar. Semaphorin 3A has been found to inhibit tumor development whereas semaphorin 6A may contribute to tumor progression.9 Neuropilins are the ligand binding moieties in the class 3 Semaphorin receptor complexes that subsequently activate signaling through associated plexins. Two types have been identified so far: Neuropilin-1 (Npn-1) and Neuropilin-2 (Npn-2) receptors. At the amino acid sequence level, Npn-1 and Npn-2 share 44% identity. Npn-1 and Npn-2 show different expression patterns in developing neurons of the central and peripheral nervous systems, and show different binding specificities for different members of he semaphorin family. Both also function as receptors for some forms of vascular endothelial growth factor (VEGF).12 Netrins are a family of laminin-related small proteins that are involved in axon guidance and eurite outgrowth. Netrin-1 has been shown to attract cortical growth cones and promote axon branching.10 Netrin-4 (first named b-netrin) was found to promote neurite elongation from olfactory bulb explants.

Bioinformatics

Uniprot Human
Human
Human
Mouse
Mouse
Product By Gene ID 9423
Alternate Names
  • netrin-1
  • NTN1Lnetrin 1, mouse, homolog of
  • netrin 1

Research Areas for Netrin-1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

PTMs for Netrin-1

Learn more about PTMs related to Netrin-1.

Phosphorylation

Bioinformatics Tool for Netrin-1

Discover related pathways, diseases and genes to Netrin-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.