Nestin Antibody (196908) [NL637]

Product Discontinued

Nestin Antibody (196908) [NL637] Summary

• Specificity: Detects human Nestin.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: NES

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Nestin Antibody (196908) [NL637]

• FLJ21841
• NES
• Nestin

Background

Nestin is a class VI intermediate filament protein (1, 2) that is expressed in stem cells of the central nervous system (CNS) (3) but not in mature CNS cells (4). Nestin expression is used extensively as a marker for CNS stem cells in the developing nervous system and in vitro cultured cells (5-10). Its transient expression is a critical step in the neural differentiation pathway (2). Nestin is also expressed in non-neural stem cell populations, such as pancreatic islet progenitors (11-13) and hematopoietic progenitors (14).

1. Hockfield, S. and R.D. McKay (1985) J. Neurosci. 5:3310.
2. Lendahl, U. et al. (1990) Cell 60:585.
3. Frederiksen, K. and R.D. McKay (1988) J. Neurosci. 8:1144.
4. Tohyama, T. et. al. (1992) Lab. Invest. 66:303.
5. Uchida, N. et al. (2000) Proc. Natl. Acad.Sci. USA 97:14720.
6. Frederiksen, K. et al. (1988) Neuron 1:439.
7. Cattaneo, E. et al. (1990) Nature 347:762.
8. Reynolds, B.A. and S. Weiss (1992) Science 255:1707.
9. Rietze, R.L. et al. (2001) Nature 412:736.
10. Carpenter, M.K. et al. (2001) Exp. Neurol 172:383.
11. Zulewski, H. et al. (2001) Diabetes 50:521.
12. Lumelsky, N. et al. (2001) Science 292:1389.
13. Lechner, A. et al. (2002) Biochem.Biophys. Res. Commun. 293:670.
14. Shih, C.C. et al. (2001) Blood 98:2412.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NES