NCOA6 Antibody [Janelia Fluor® 635]

Product Discontinued

NCOA6 Antibody [Janelia Fluor® 635] Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residue 2000 and the C-terminus (residue 2063) of human Activating Signal Cointegrator-2 using the numbering given in Swiss-Prot entry Q14686 (GeneID 23054).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NCOA6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for NCOA6 Antibody [Janelia Fluor® 635]

• Activating signal cointegrator 2
• AIB3NRC RAP250
• Amplified in breast cancer protein 3
• ASC-2
• Cancer-amplified transcriptional coactivator ASC-2
• KIAA0181PPAR-interacting protein
• NRCamplified in breast cancer-3 protein
• nuclear receptor coactivator 6
• Nuclear receptor coactivator RAP250
• Nuclear receptor-activating protein, 250 kDa
• peroxisome proliferator-activated receptor interacting protein
• PRIPPeroxisome proliferator-activated receptor-interacting protein
• RAP250Thyroid hormone receptor-binding protein
• thyroid hormone receptor binding protein
• TRBPASC2activating signal cointegrator-2

Background

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. NCOA6 is over-expressed in several breast cancer cell lines.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NCOA6