MuSK Antibody

Images

 
Recombinant Rat Agrin (Catalog # 550-AG) induces MuSK-dependent acetylcholine receptor clustering on myotubes differentiated from the C2C12 mouse myoblast cell line in a dose-dependent manner (orange line). ...read more

Product Details

Summary
Reactivity RtSpecies Glossary
Applications WB, B/N
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Conjugate Size Price
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Catalog# & Formulation Size Price

MuSK Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant rat MuSK
Specificity
Detects rat MuSK in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
MUSK
Purity
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Neutralization 0.5-2 ug/mL
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF562 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MuSK Antibody

  • EC 2.7.10
  • EC 2.7.10.1
  • MGC126323
  • MGC126324
  • muscle, skeletal, receptor tyrosine kinase
  • MuSK
  • skeletal receptor tyrosine-protein kinase

Background

MuSK (Muscle-Specific Kinase) is a receptor tyrosine kinase expressed in muscle that regulates the formation of the neuromuscular junction. It binds the heparin sulfate proteoglycan Agrin to promote Acetylcholine Receptor clustering.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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AF562
Species: Rt
Applications: WB, B/N

Publications for MuSK Antibody (AF562)(11)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: ICC, Immunoprecipitation, Neutralization, Western Blot.


Filter By Application
ICC
(1)
Immunoprecipitation
(4)
Neutralization
(1)
Western Blot
(5)
All Applications
Filter By Species
Human
(3)
Mouse
(7)
Rat
(1)
All Species
Showing Publications 1 - 10 of 11. Show All 11 Publications.
Publications using AF562 Applications Species
J Oury, W Zhang, N Leloup, A Koide, AD Corrado, G Ketavarapu, T Hattori, S Koide, SJ Burden Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia Nature, 2021;0(0):. 2021 [PMID: 34163073] (Western Blot, Mouse) Western Blot Mouse
K Takata, P Stathopoul, M Cao, M Mané-Damas, ML Fichtner, ES Benotti, L Jacobson, P Waters, SR Irani, P Martinez-M, D Beeson, M Losen, A Vincent, RJ Nowak, KC O'Connor Characterization of pathogenic monoclonal autoantibodies derived from muscle-specific kinase myasthenia gravis patients JCI Insight, 2019;4(12):. 2019 [PMID: 31217355] (Immunoprecipitation, Mouse) Immunoprecipitation Mouse
S Huda, P Waters, M Woodhall, MI Leite, L Jacobson, A De Rosa, M Maestri, R Ricciardi, JM Heckmann, A Maniaol, A Evoli, J Cossins, D Hilton-Jon, A Vincent IgG-specific cell-based assay detects potentially pathogenic MuSK-Abs in seronegative MG Neurol Neuroimmunol Neuroinflamm, 2017;4(4):e357. 2017 [PMID: 28626780] (ICC, Human) ICC Human
S Miyoshi, T Tezuka, S Arimura, T Tomono, T Okada, Y Yamanashi DOK7 gene therapy enhances motor activity and life span in ALS model mice EMBO Mol Med, 2017;0(0):. 2017 [PMID: 28490573] (Western Blot, Mouse) Western Blot Mouse
Raphael Vezina-Aud Laminin is Instructive and Calmodulin Dependent Kinase II is Non-Permissive for the Formation of Complex Aggregates of Acetylcholine Receptors on Myotubes in Culture Matrix Biol, 2016;0(0):. 2016 [PMID: 27964993] (Neutralization, Mouse) Neutralization Mouse
Koneczny , Inga, Cossins , Judith, Waters , Patrick, Beeson , David, Vincent , Angela MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters. PLoS ONE, 2013;8(11):e80695. 2013 [PMID: 24244707] (Immunoprecipitation, Human) Immunoprecipitation Human
Littleton E, Dreger M, Palace J Immunocapture and identification of cell membrane protein antigenic targets of serum autoantibodies. Mol. Cell Proteomics, 2009;8(7):1688-96. 2009 [PMID: 19332416] (Western Blot, Human) Western Blot Human
Hamuro J, Higuchi O, Okada K, Ueno M, Iemura S, Natsume T, Spearman H, Beeson D, Yamanashi Y Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7. J. Biol. Chem., 2007;283(9):5518-24. 2007 [PMID: 18165682] (Western Blot, Mouse) Western Blot Mouse
Garcia-Osta A, Tsokas P, Pollonini G, Landau EM, Blitzer R, Alberini CM MuSK expressed in the brain mediates cholinergic responses, synaptic plasticity, and memory formation. J. Neurosci., 2006;26(30):7919-32. 2006 [PMID: 16870737] (Western Blot, Mouse) Western Blot Mouse
Strochlic L, Cartaud A, Mejat A, Grailhe R, Schaeffer L, Changeux JP, Cartaud J 14-3-3 gamma associates with muscle specific kinase and regulates synaptic gene transcription at vertebrate neuromuscular synapse. Proc. Natl. Acad. Sci. U.S.A., 2004;101(52):18189-94. 2004 [PMID: 15604144] (Immunoprecipitation, Rat) Immunoprecipitation Rat
Show All 11 Publications.

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Bioinformatics

Gene Symbol MUSK