Musashi-1 Antibody

Product Discontinued

Musashi-1 Antibody Summary

• Immunogen: Reacts with residues 5-21 [APQPGLASPDSPHDPCK] of the human, mouse and rat Musashi 1 protein.
• Marker: Neuronal Stem Cell Marker
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MSI1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:100-200
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:100-200
  • Western Blot 1:500

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for Musashi-1 Antibody

• MSI1
• Musashi (Drosophila) homolog 1
• musashi homolog 1 (Drosophila)
• Musashi1
• Musashi-1
• RNA-binding protein Musashi homolog 1

Background

Musashi1, a neural RNA-binding protein, plays an important role in regulating cell differentiation in precursor cells. Musashi-1 (Msi-1) has been shown to increase the accumulation of tau isoforms in intracellular inclusions in dementia. It may play a role in the pathogenesis of various neurodegenerative disorders. Musashi1 has also been detected in human tumor tissues such as gliomas and melanomas, suggesting its involvement in cancer development. Msi-1 also appears to play be an vital role in the development of several types of carcinoma such as human hepatoma, and may be a useful molecular marker for tumor detection.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Musashi-1 Antibody (NBP2-30106)(1)

Publication using NBP2-30106

• Kanwar SS, Yu Y, Nautiyal J et al. The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. Mol Cancer. 2010-08-06 [PMID: 20691072]
  
  Details:
  Musashi-1 (IMG-4982A). WB: HT-29, HCT-116, and HCT-116 p53 -/- cell lines, Fig 1B. Note: Musashi-1 was detected at 35 kDa. Regulation of autologous immunity to the mouse 5T4 oncofoetal antigen: implications for immunotherapy. 4APC (IMG-6217G).

Bioinformatics

• Gene Symbol: MSI1
• Uniprot:
  • NP_002433(Human)